Climbazole

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Climbazole
Climbazole.svg
Clinical data
Routes of
administration
topical
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
ECHA InfoCard100.048.870 Edit this at Wikidata
Chemical and physical data
FormulaC15H17ClN2O2
Molar mass292.76
3D model (JSmol)
ChiralityRacemic mixture
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Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations[edit]

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects[edit]

May cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]

References[edit]

  1. ^ Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine.
  2. ^ a b Wigger-Alberti, W; Kluge, K; Elsner, P (2001). "Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema". Praxis. 90 (33): 1346–9. PMID 11534318.