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Clinical endocannabinoid deficiency syndrome

From Wikipedia, the free encyclopedia

Clinical endocannabinoid deficiency (CECD) is a medical theory that proposes that a deficiency of endocannabinoids is the underlying pathophysiology of migraines, fibromyalgia, and irritable bowel syndrome.[1][2] The deficiency may sometimes start in the womb as a result of maternal obesity.[3]

The nature of the syndrome and existence of CECD as a clinically meaningful condition have been called into question.[4]


  1. ^ Russo, EB (2004). "Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?". Neuro Endocrinology Letters. 25 (1–2): 31–9. PMID 15159679.
  2. ^ Russo, EB (2016). "Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes". Cannabis and Cannabinoid Research. 1 (1): 154–165. doi:10.1089/can.2016.0009. PMC 5576607. PMID 28861491.
  3. ^ Schlabritz-Loutsevitch, N, et al. (2016). "Fetal Syndrome of Endocannabinoid Deficiency (FSECD) in Maternal Obesity". Medical Hypotheses. 96: 35–38. doi:10.1016/j.mehy.2016.09.021. PMID 27959272.
  4. ^ Cogan, PS (2020). "Practical Considerations of Hypotheses and Evidence in Cannabis Pharmacotherapy: Refining Expectations of Clinical Endocannabinoid Deficiency". Journal of Dietary Supplements. 17 (5): 608–624. doi:10.1080/19390211.2020.1769246. PMID 32449630.