Clitocine

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Clitocine
Clitocine.svg
Names
IUPAC name
(2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
Identifiers
3D model (JSmol)
ChemSpider
Properties
C9H13N5O6
Molar mass 287.23 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Clitocine is a mushroom nucleoside isolate with anticancer activity in vitro.[1][2][3]

References[edit]

  1. ^ "Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis". 262 (2). April 2008: 190–200. PMID 18222036. doi:10.1016/j.canlet.2007.12.013. 
  2. ^ "Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line". PLoS ONE. 7 (8): e40720. 2012. PMC 3425549Freely accessible. PMID 22927901. doi:10.1371/journal.pone.0040720. 
  3. ^ "Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo". Apoptosis. 19 (5): 871–82. May 2014. PMID 24563182. doi:10.1007/s10495-014-0969-0.