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Clinical data
Routes of
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
CAS Number
PubChem CID
Chemical and physical data
Formula C14H21ClN2O2
Molar mass 284.78 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Clovoxamine (INN) (developmental code name DU-23811) is a drug that was discovered in the 1970s and was subsequently investigated as an antidepressant and anxiolytic agent but was never marketed.[1][2][3] It acts as a serotonin-norepinephrine reuptake inhibitor (SNRI), with little affinity for the muscarinic acetylcholine, histamine, adrenergic, and serotonin receptors.[4][5] The compound is structurally related to fluvoxamine.


  1. ^ Freeman; Wakelin, J. S.; Calanca, A.; Hole, G. (1982). "Initial clinical evaluation of a new nontricyclic antidepressant: clovoxamine". Advances in Biochemical Psychopharmacology. 32: 69–75. PMID 7046368. 
  2. ^ Jesinger; Gostick, N. (1989). "Anxiety neurosis in general practice. A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake". International clinical psychopharmacology. 4 (4): 301–311. doi:10.1097/00004850-198910000-00005. PMID 2691573. 
  3. ^ Hurst; Jones, D. R.; Wright, J. H.; Jarboe, C. H. (1983). "Clovoxamine kinetics in an early clinical trial". Clinical pharmacology and therapeutics. 34 (2): 266–271. doi:10.1038/clpt.1983.164. PMID 6872422. 
  4. ^ Saletu; Grünberger, J.; Rajna, P.; Karobath, M. (1980). "Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man". Journal of neural transmission. 49 (1–2): 63–86. doi:10.1007/BF01249190. PMID 6777458. 
  5. ^ Bradford; Tulp, M. T.; Schipper, J. (1987). "Biochemical effects in rats after acute and long-term treatment with clovoxamine". Archives Internationales de Pharmacodynamie et de Thérapie. 287 (2): 188–202. PMID 2820327.