Clumping factor A

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Clumping factor A, or ClfA, is a virulence factor from Staphylococcus aureus (S. aureus) that binds to fibrinogen.

ClfA also has been shown to bind to complement regulator I protein.[1]

It is responsible for the clumping of blood plasma observed when adding S. aureus to human plasma. Clumping factor can be detected by the slide test.

See also[edit]


  1. ^ Hair PS, Ward MD, Semmes OJ, Foster TJ, Cunnion KM (July 2008). "Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b". The Journal of Infectious Diseases. 198 (1): 125–33. doi:10.1086/588825. PMID 18544012.