Cob(II)yrinic acid a,c-diamide reductase

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cob(II)yrinic acid a,c-diamide reductase
Identifiers
EC number 1.16.8.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) is an enzyme that catalyzes the chemical reaction

Cob(II)yrinic acid a,c-diamide reductase.svg
2 cob(I)yrinic acid a,c-diamide + FMN + 3 H+ 2 cob(II)yrinic acid a,c-diamide + FMNH2

The 3 substrates of this enzyme are cob(I)yrinic acid a,c-diamide, FMN, and H+, whereas its two products are cob(II)yrinic acid a,c-diamide and FMNH2.

Classification[edit]

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor.

Nomenclature[edit]

The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect).

Biological role[edit]

This enzyme participates in porphyrin and chlorophyll metabolism.

References[edit]

  • Blanche F, Maton L, Debussche L, Thibaut D (1992). "Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans". J. Bacteriol. 174 (22): 7452&ndash, 4. PMC 207442. PMID 1429467.
  • Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390&ndash, 412. doi:10.1039/b108967f. PMID 12195810.