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NAD-dependent deacetylase
CobB NAD dependent deacetylase 1S5P.png
Crystallographic structure of the CobB protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with a portion of histone H4 (magenta) where the sidechain of acylated lysine-16 is displayed as stick diagram.[1]
Symbol npdA
Alt. symbols cobB, ycfY
Entrez 945687
UniProt P75960

CobB is a bacterial protein that belongs to the sirtuin family, a broadly conserved family of NAD+-dependent protein deacetylases.[2][3]


  1. ^ PDB: 1S5P​; Zhao K, Chai X, Marmorstein R (March 2004). "Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli". J. Mol. Biol. 337 (3): 731–41. doi:10.1016/j.jmb.2004.01.060. PMID 15019790. 
  2. ^ Starai VJ, Celic I, Cole RN, Boeke JD, Escalante-Semerena JC (December 2002). "Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine". Science. 298 (5602): 2390–2. doi:10.1126/science.1077650. PMID 12493915. 
  3. ^ Schwer B, Verdin E (February 2008). "Conserved metabolic regulatory functions of sirtuins". Cell Metab. 7 (2): 104–12. doi:10.1016/j.cmet.2007.11.006. PMID 18249170.