Adenosylcobalamin

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Adenosylcobalamin
AdoCbl-ColorCoded.png
Cobamamide 3D sticks.png
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEBI
ECHA InfoCard100.034.192 Edit this at Wikidata
Chemical and physical data
FormulaC72H100CoN18O17P
Molar mass1579.58 g/mol g·mol−1
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Adenosylcobalamin (AdoCbl), also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin (MeCbl), one of the biologically active forms of vitamin B12.[1]

Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosyl radical through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with an bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme active site.[2] An enzyme that uses adenosylcobalamin as a cofactor is methylmalonyl-CoA mutase (MCM).

References[edit]

  1. ^ Marsh EN, Meléndez GD (November 2012). "Adenosylcobalamin enzymes: theory and experiment begin to converge". Biochimica et Biophysica Acta. 1824 (11): 1154–64. doi:10.1016/j.bbapap.2012.03.012. PMC 3580769. PMID 22516318.
  2. ^ Kräutler B, Arigoni D, Golding BT (1998). Vitamin B12 and B12-proteins : lectures presented at the 4th European Symposium on Vitamin B12 and B12-Proteins. Weinheim: Wiley-VCH. ISBN 9783527612192. OCLC 212131311.

External links[edit]