Collagen, type XII, alpha 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
COL12A1
Identifiers
Aliases COL12A1, BA209D8.1, COL12A1L, DJ234P15.1, BTHLM2, UCMD2, collagen type XII alpha 1
External IDs MGI: 88448 HomoloGene: 3217 GeneCards: 1303
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004370
NM_080645

NM_001290308
NM_007730

RefSeq (protein)

NP_004361.3
NP_542376.2

NP_001277237.1

Location (UCSC) Chr 6: 75.08 – 75.21 Mb Chr 9: 79.6 – 79.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene.[1][2]

This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References[edit]

  1. ^ Gerecke DR, Olson PF, Koch M, Knoll JH, Taylor R, Hudson DL, Champliaud MF, Olsen BR, Burgeson RE (Jul 1997). "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics 41 (2): 236–42. doi:10.1006/geno.1997.4638. PMID 9143499. 
  2. ^ a b "Entrez Gene: COL12A1 collagen, type XII, alpha 1". 

Further reading[edit]