Collagen, type XXV, alpha 1

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COL25A1
Identifiers
Aliases COL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1
External IDs MGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256074
NM_032518
NM_198721

NM_001244952
NM_029838
NM_198711

RefSeq (protein)

NP_001243003
NP_115907
NP_942014

NP_084114.2
NP_001231881
NP_084114
NP_942004

Location (UCSC) Chr 4: 108.81 – 109.3 Mb Chr 3: 130.13 – 130.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[3][4]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][4]

Interactions[edit]

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364Freely accessible. PMID 11927537. 
  4. ^ a b "Entrez Gene: COL25A1 collagen, type XXV, alpha 1". 

Further reading[edit]