Collagen VI is a form of collagen primarily associated with the extracellular matrix of skeletal muscle. Collagen VI is known to maintain muscle function regularity as well as cell membrane integrity. Collagen VI molecules are made up of three alpha chains: α1(VI), α2(VI), and α3(VI). It is associated with the genes COL6A1, COL6A2, COL6A3 and COL6A5. The chain lengths of α1(VI) and α2(VI) are about 1,000 amino acids. The chain length of α3(VI) is roughly a third larger than those of α1(VI) and α2(VI), and it consists of several spliced variants within the range of 2,500 to 3,100 amino acids.
The first two alpha chains subunits of collagen VI have a molecular weight of 140-150 KDa and the third polypeptide chain is larger with a molecular weight of 250-300kDa. Collagen VI is also found in the skin, lungs, blood vessels, cornea and intervertebral disc. It also forms part of the peripheral nerves, brain, myocardium and adipose tissue. There has been recent discoveries of Collagen VI including Col64, Col65 and Col66. 
- It provides plants with structural support by forming a mesh of beaded microfilament.
- It plays an important role in cancer by acting as a chemotherapy resistance modulator 
- They are known to anchor the basement membrane of the skin to the extracellular matrix which occurs with the help of other collagens, proteoglycans, matrilines, fibronectin and glycoprotein 1.
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