Collagenous spherulosis

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Collagenous spherulosis
Collagenous spherulosis - very high mag.jpg
Micrograph of collagenous spherulosis with the characteristic histomorphology - intratubular eosinophilic material with a spoke-like arrangement. H&E stain.
Classification and external resources

Collagenous spherulosis, also mucinous spherulosis and simply spherulosis, is a benign finding in breast pathology. It is almost always an incidental finding, though it is occasionally associated with calcifications, which may lead to a biopsy.


It is important to correctly identify, as it can be confused with atypical ductal hyperplasia, cribriform ductal carcinoma in situ (DCIS), and adenoid cystic carcinoma.[1]

Histomorphologic features[edit]

Collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular eosinophilic material that classically is arranged like the spokes of a wheel ("radial spikes"). There is usually no mitotic activity, and two cells populations (epithelial & myoepithelial) are present, like in benign breast glands.

The lesions are typically small (less than 50 spherules per lesion, less than 100 micrometers in size) and may be multifocal.

See also[edit]

Additional images[edit]


  1. ^ Resetkova, E.; Albarracin, C.; Sneige, N. (Jan 2006). "Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature.". Am J Surg Pathol. 30 (1): 20–7. doi:10.1097/01.pas.0000179237.91515.81. PMID 16330938. 

External links[edit]