Combined pulmonary fibrosis and emphysema

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Combined pulmonary fibrosis and emphysema
Other namesCPFE
SpecialtyPulmonology

Combined pulmonary fibrosis and emphysema (CPFE), describes a medical syndrome involving both pulmonary fibrosis and emphysema.[1][2] The combination is most commonly found in male smokers. Pulmonary function tests typically show preserved lung volume with very low transfer factor.[3]

CFPE is characterised by shortness of breath, and reduced oxygen concentration (reflecting gas exchange abnormalities). Imaging shows upper-lobe emphysema, and lower-lobe interstitial fibrosis.[4] CFPE is often complicated by pulmonary hypertension, acute lung injury, lung cancer, and coronary artery disease.[4]

The diagnosis is confirmed with high resolution CT scan.[5]

References[edit]

  1. ^ Cottin, V; Cordier JF (June 2005). "Combined pulmonary fibrosis and emphysema: an experimental and clinically relevant phenotype". American Journal of Respiratory and Critical Care Medicine. 172 (12): 1605, author reply 1605–6. doi:10.1164/ajrccm.172.12.1605a. PMID 16339012.
  2. ^ Cottin, V; Nunes H; Brillet PY; et al. (February 2006). "Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity". European Respiratory Journal. 26 (4): 586–593. doi:10.1183/09031936.05.00021005. PMID 16204587.
  3. ^ Papiris, SA; Triantafillidou, C; Manali, ED (February 2013). "Combined pulmonary fibrosis and emphysema". Expert Review of Respiratory Medicine. 7 (1): 19–31. doi:10.1586/ers.12.80. PMID 23362797.
  4. ^ a b Wand, O; Kramer, MR (January 2018). "The Syndrome of Combined Pulmonary Fibrosis and Emphysema - CPFE". Harefuah. 157 (1): 28–33. PMID 29374870.
  5. ^ Jankowich, MD; Rounds, SI (January 2012). "Combined pulmonary fibrosis and emphysema syndrome: a review". Chest. 141 (1): 222–231. doi:10.1378/chest.11-1062. PMC 3251269. PMID 22215830.

External links[edit]

Classification
External resources