Commanders: Attack of the Genos tells the story of an alternate history, one in which humanity has discovered the secrets of atomic energy right at the opening of the 20th Century. By the year 1924, technology as accelerated to the point where humans have cracked the human genome, and have managed to create a whole new race of genetically modified lifeforms, dubbed Genos. Genos have been developed to be stronger, faster, and generally better on the whole than the rest of the human race, causing the rest of the world to resent the Genos. This results in their eventual exile to another land. While a tenuous peace existed between the two races for some time, the start of the game seems to indicate that the time for peace has passed, as the Genos invade.