Complement component 1R

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complement component 1, r subcomponent
Symbol C1R
Entrez 715
HUGO 1246
OMIM 216950
RefSeq NM_001733
UniProt P00736
Other data
EC number
Locus Chr. 12 p13

Complement component 1R (EC, activated complement C1r, C overbar 1r esterase, activated complement C1r) is a protein involved in the complement system.[1][2][3] This enzyme catalyses the following chemical reaction

Selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form C verbar 1s (EC


  1. ^ Sim, R.B. (1981). "The human complement system serine proteases C1r and C1s and their proenzymes". Methods Enzymol. 80: 26–42. PMID 6281620. doi:10.1016/s0076-6879(81)80006-7. 
  2. ^ Leytus, S.P.; Kurachi, K.; Sakariassen, K.S.; Davie, E.W. (1986). "Nucleotide sequence of the cDNA coding for human complement C1r". Biochemistry. 25: 4855–4863. PMID 3021205. doi:10.1021/bi00365a020. 
  3. ^ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. PMID 3052276. doi:10.1146/ 

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