Complement component 1s

From Wikipedia, the free encyclopedia
Jump to: navigation, search
complement component 1, s subcomponent
Symbol C1S
Entrez 716
HUGO 1247
OMIM 120580
RefSeq NM_001734
UniProt P09871
Other data
EC number
Locus Chr. 12 p13

Complement component 1S (EC, C1 esterase, activated complement C1s, complement C overbar 1r ) is a protein involved in the complement system.[1][2][3][4]

C1s cleaves C4, which eventually leads to the production of the C4b-C2a form of C3-convertase.

Classical pathway. (Some labels are in Polish.)


  1. ^ Sim, R.B. (1981). "The human complement system serine proteases C1r and C1s and their proenzymes". Methods Enzymol. 80: 26–42. PMID 6281620. doi:10.1016/s0076-6879(81)80006-7. 
  2. ^ MacKinnon, C.M.; Carter, P.E.; Smyth, S.J.; Dunbar, B.; Fothergill, J.E. (1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". Eur. J. Biochem. 169: 547–553. PMID 3500856. doi:10.1111/j.1432-1033.1987.tb13644.x. 
  3. ^ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. PMID 3052276. doi:10.1146/ 
  4. ^ Skoog, M.T.; Mehdi, S.; Wiseman, J.S.; Bey, P. (1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochim. Biophys. Acta. 996 (1-2): 89–94. PMID 2500154. doi:10.1016/0167-4838(89)90099-x. 

External links[edit]