Complement component 9

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
C9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC9, ARMD15, C9D, complement component 9, complement C9
External IDsOMIM: 120940 MGI: 1098282 HomoloGene: 74406 GeneCards: C9
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for C9
Genomic location for C9
Band5p13.1Start39,284,140 bp[1]
End39,424,868 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001737

NM_013485
NM_001368420
NM_001368421

RefSeq (protein)

NP_001728

NP_038513
NP_001355349
NP_001355350

Location (UCSC)Chr 5: 39.28 – 39.42 MbChr 15: 6.45 – 6.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system.[5] C9 is a member of the complement membrane attack complex (MAC) and induces pores on cell membranes, causing lysis. There are 10-16 molecules of C9 in a single membrane attack complex (MAC), along with one of each of the complement components C5b, C6, C7 and C8.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113600 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022149 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lint TF, Zeitz HJ, Gewurz H (November 1980). "Inherited deficiency of the ninth component of complement in man". J. Immunol. 125 (5): 2252–7. PMID 7430628.
  6. ^ Janeway, CA Jr; Travers P; Walport M; et al. (2001). "The complement system and innate immunity". Immunobiology: The Immune System in Health and Disease. New York: Garland Science. Retrieved 29 December 2017.

External links[edit]