Complement factor B

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CFB
Protein CFB PDB 1dle.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CFB, Cfb, AI195813, AI255840, B, Bf, C2, Fb, H2-Bf, AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, PBF2, complement factor B
External IDs MGI: 105975 HomoloGene: 1292 GeneCards: CFB
Genetically Related Diseases
age related macular degeneration[1]
RNA expression pattern
PBB GE CFB 202357 s at tn.png

PBB GE CFB 211920 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001710

NM_001142706
NM_008198

RefSeq (protein)

NP_001701

NP_001136178
NP_032224

Location (UCSC) Chr 6: 31.95 – 31.95 Mb Chr 17: 34.86 – 34.86 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Complement factor B is a protein that in humans is encoded by the CFB gene.[4]

Function[edit]

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.[4]

Alternative pathway. (Some labels are in Polish.)
Complement tests
C4 (C) FB (A) C3 CH50 Conditions
 · PSG, C3 NeF AA
 ·  · HA, C4D
 ·  ·  · TCPD
 · /↓ SLE
inflammation

References[edit]

Further reading[edit]

External links[edit]