Complement receptor

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A complement receptor is a receptor of the complement system, a part of the mediated innate immune system. Complement receptors are responsible for detecting pathogens by mechanisms not mediated by antibodies. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore, complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.

Complement receptors[edit]

All four complement receptors bind to complement component 3 or complement component 4 fragments on pathogen surface, but they are different in functions. Complement receptor (CR) 1, 3, and 4 work as opsonin. On the other hand, CR2 is a kind of B cell co-receptor.

Red blood cells (RBCs) also express CR1. With these receptors, RBCs bring antigen-antibody complex in blood to liver and spleen for degradation.[1]

Types include:

CR # Name CD
CR1 - CD35
CR2 - CD21
CR3 Macrophage-1 antigen or "integrin alphaMbeta2" CD11b+CD18
CR4 Integrin alphaXbeta2 or "p150,95" CD11c+CD18
- C3a receptor -
- C5a receptor CD88
- C1q receptor -

Clinical significance[edit]

Defects in these receptors can be associated with disease.[2]

See also[edit]


  1. ^ Peter Parham, The Immune System (2nd ed.), Taylor&Francis 
  2. ^ "Complement Receptor Deficiency: eMedicine Dermatology". Retrieved 2010-12-07. 

External links[edit]