From Wikipedia, the free encyclopedia
Monoclonal antibody
TypeWhole antibody
TargetTRAIL-R2 (CD262)
Clinical data
Other namesanti-TRAIL receptor 2 monoclonal antibody, AMG-655
ATC code
  • none
CAS Number
  • none
Chemical and physical data
Molar mass145645.66 g·mol−1
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Conatumumab (originally AMG-655) is a monoclonal antibody developed for the treatment of cancer. It is a fully human monoclonal agonist antibody directed against the extracellular domain of human TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) receptor 2 (TR-2, death receptor 5) with potential antineoplastic activity.[1][2] Conatumumab mimics the activity of native TRAIL, binding to and activating TR-2, thereby activating caspase cascades and inducing tumor cell apoptosis. TR-2 is expressed by a variety of solid tumors and cancers of hematopoietic origin.[3][4]

The drug was developed by Amgen Inc. In 2008, Takeda licensed the drug from Amgen for development in Japan, but discontinued development in 2011.


  1. ^ Rosevear HM, Lightfoot AJ, Griffith TS (June 2010). "Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer". Current Opinion in Investigational Drugs. London, England. 11 (6): 688–98. PMID 20496264.
  2. ^ Bajaj M, Heath EI (November 2011). "Conatumumab: a novel monoclonal antibody against death receptor 5 for the treatment of advanced malignancies in adults". Expert Opinion on Biological Therapy. 11 (11): 1519–24. doi:10.1517/14712598.2011.610788. PMID 21877997. S2CID 28520935.
  3. ^ Statement On A Nonproprietary Name Adopted By The USAN Council – Conatumumab, American Medical Association.
  4. ^ National Cancer Institute: Definition of conatumomab