Condensation particle counter
A condensation particle counter or CPC is a particle counter that detects and counts aerosol particles by first enlarging them by using the particles as nucleation centers to create droplets in a supersaturated gas. 
Three techniques have been used to produce nucleation:
- Adiabatic expansion using an expansion chamber. This was the original technique used by John Aitken in 1888. 
- Thermal diffusion.
- Mixing of hot and cold gases. 
Condensation particle counters are able to detect particles with dimensions from 2 nm and larger. This is of special importance because particles sized down from 50 nm are generally undetectable with conventional optical techniques. Usually the supersaturation is ca. 100…200 % in condensation chamber, despite the fact that heterogeneous nucleation (droplet growth on surface of a suspended solid particle) can occur at supersaturation as small as 1 %. The greater vapour content is needed because, according to surface science laws, the vapour pressure over a convex surface is less than over a plane, thus greater content of vapor in air is required to meet actual supersaturation criteria. This amount grows (vapor pressure decreases) along with decrease in particle size, the critical diameter for which condensation can occur at the present saturation level is called Kelvin diameter. The supersaturation level must, however, be small enough to prevent homogeneous nucleation (when liquid molecules collide so often that they form clusters – stable enough to ensure further growth is possible), which will produce false counts. This usually starts at ca. 300 % supersaturation. 
Operation of a diffusional thermal cooling CPC is depicted on the right. Air passes through a hollow block of porous material in contact with the working liquid, the block being heated to ensure high vapour content. Then the humified air enters the cooler where nucleation occur. Temperature difference between the heater and the cooler determines the supersaturation, which in its turn determines the minimal size of particles that will be detected (the greater the difference, the smaller particles get counted). As proper nucleation conditions occur in the center of the flow, sometimes incoming flow is divided: most of it undergoes filtering and forms the sheath flow, which the rest of flow, still containing particles, is inserted into via a capillary. The more uniform is obtained supersaturation, the sharper is particle minimal size cutoff. During the heterogeneous nucleation process in the nucleation chamber, particles grow up to 10…12 μm large and so are conveniently detected by usual techniques, such as laser nefelometry (measurement of light pulses scattered by the grown-up particles).
- "General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories". U.S. National Institute for Occupational Safety and Health. May 2012. pp. 29–30. Retrieved 2017-03-05.
- Aerosol Measurement: Principles, Techniques, and Applications, edited by Pramod Kulkarni, Paul A. Baron, Klaus Willeke, p384,  retrieved 15 May 2012
- Kulkarni, Baronand and Willeke, p381
- Condensation Particle Counters (CPC)