Stamati became a civil servant and official translator under the first Russian administration of the region. He was rewarded by the Russian Emperor with the Medal of Saint Anne and became a knight of that order.
He made the acquaintance of the Russian poet Alexander Pushkin at the time of latter's exile to Chişinău in 1820-1823. Stamati's most important work, Povestea poveştilor ("The Tale of Tales"), an idealized description of Moldavia's beginnings in verse, was published in Iaşi in 1843. His other works include contemporary satires and glorifications of Moldavia's past.