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Manos comes from Kastoria, Macedonia, and descend from the founder of the family, Emmanuel (Manos) Philippou (1610 - 1699). His grandson Manolaki (born circa 1655) settled, the first of the family, in Constantinople becoming a powerful fur trader and later Megas logothetes of the Ecumenical Patriarchate. Much of the family later settled in the independent Greek Kingdom. Further prominence for the family ensued from the controversial marriage of Aspasia Manos to King Alexander I of Greece.
Its members include:
- Konstantinos Manos (1869–1913), politician and writer, resided in Chania, Crete
- Petros Manos (1871–1918), colonel, younger brother of Konstantinos; father of Aspasia (below) who became king's wife
- Aspasia Manos (1896–1972), daughter of Petros (above), wife of King Alexander of Greece, mother of Alexandra, Queen of Yugoslavia and grandmother of the current Alexander, Crown Prince of Yugoslavia
- Ileana Manos (b. 1971), great-granddaughter of Konstantinos (above); current Duchess of Chartres as wife of Prince Charles Louis, Duke of Chartres
- John B. Manos (b. 1971), great-grandson of Petros (above); currently a U.S. attorney; no diplomatic status as he was severed from the family when it was discovered he had been baptized Roman Catholic. Graduate of the Inaugural class of Ave Maria School of Law; ironically is also a Kentucky Colonel like Petros.
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