Conversion disorder

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Conversion disorder
Classification and external resources
Specialty Psychiatry
ICD-10 F44
ICD-9-CM 300.11
DiseasesDB 1645
MedlinePlus 000954
eMedicine emerg/112 med/1150
MeSH D003291

Conversion disorder (CD) is a diagnostic category previously used in some psychiatric classification systems. It is sometimes applied to patients who present with neurological symptoms, such as numbness, blindness, paralysis, or fits, which are not consistent with a well-established organic cause, and which cause significant distress. It is thought that these symptoms arise in response to stressful situations affecting a patient's mental health or an ongoing mental health condition such as depression. Conversion Disorder was removed from the DSM, and replaced with the umbrella term Functional Neurological Symptom Disorder in the DSM-V. Functional Neurological Symptom Disorder covers the same range of symptoms, however removes the requirement for a psychological stressor to be present. Doctors are now advised not to use the term 'Conversion Disorder' when diagnosing patients.

The theory of Conversion Disorder stems from ancient Egypt, and was also formerly known as "hysteria". The concept of conversion disorder came to prominence at the end of the 19th century, when the neurologists Jean-Martin Charcot, Sigmund Freud and psychologist Pierre Janet focused their studies on the subject. Before their studies, people with hysteria were often believed to be malingering.[1] The term "conversion" has its origins in Freud's doctrine that anxiety is "converted" into physical symptoms.[2] Though previously thought to have vanished from the west in the 20th century, some research has suggested it is as common as ever.[3]

The ICD-10 classifies conversion disorder as a dissociative disorder[4] while the DSM-IV classifies it as a somatoform disorder.

Definition[edit]

The DSM-V removed the term 'Conversion Disorder' entirely. The symptoms previously referred to as this condition were placed under the umbrella term of 'Functional Neurological Symptom This means that patients who have similar symptoms, but have no psychological stressor are now able to be given a diagnosis. Some doctors believe FND to be caused by an issue with the Central Nervous System, however due to limited research, FND remains in the DSM.

The diagnostic criteria for Conversion Disorder, as set out in the DSM-V are:

The diagnostic criteria for Functional Neurological Disorder is:

A. The patient has ≥1 symptoms of altered voluntary motor or sensory function.

B. Clinical findings provide evidence of incompatibility between the symptom and recognised neurological or medical conditions.

C. The symptom or deficit is not better explained by another medical or mental disorder.

D. The symptom or deficit causes clinically significant distress or impairment in social, occupational, or other important areas of functioning or warrants medical evaluation.

Specify type of symptom or deficit as:

  • With weakness or paralysis
  • With abnormal movement (e.g., tremor, dystonic movement, myoclonus, gait disorder)
  • With swallowing symptoms
  • With speech symptoms (e.g., dysphonia, slurred speech)
  • With attacks or seizures
  • With anaesthesia or memory loss
  • With special sensory symptom (e.g., visual, olfactory,or hearing disturbance)
  • With mixed symptoms.

Specify if:

  • Acute episode: symptoms present for less than 6 months
  • Persistent: symptoms present for 6 months or more.[5]

Specify if:

  • Psychological Stressor
  • No Psychological Stressor

Signs and symptoms[edit]

In some cases, conversion disorder begins with some stressor, trauma, or psychological distress. Usually the physical symptoms of the syndrome affect the senses or movement. Common symptoms include blindness, partial or total paralysis, inability to speak, deafness, numbness, sores, difficulty swallowing, incontinence, balance problems, seizures, tremors, and difficulty walking. These symptoms are attributed to conversion disorder when a medical explanation for the afflictions cannot be found.[6] Symptoms of conversion disorder usually occur suddenly. Conversion disorder is typically seen in individuals 10 to 35 years old.[7]

Conversion disorder can present with motor or sensory symptoms including any of the following:

Motor symptoms or deficits:

  • Impaired coordination or balance
  • Weakness/paralysis of a limb or the entire body (hysterical paralysis or motor conversion disorders)
  • Impairment or loss of speech (hysterical aphonia)
  • Difficulty swallowing or a sensation of a lump in the throat
  • Urinary retention
  • Psychogenic non-epileptic seizures or convulsions
  • Persistent dystonia
  • Tremor, myoclonus or other movement disorders
  • Gait problems (astasia-abasia)
  • Loss of consciousness (fainting)

Sensory symptoms or deficits:

  • Impaired vision (hysterical blindness), double vision
  • Impaired hearing (deafness)
  • Loss or disturbance of touch or pain sensation

Conversion symptoms typically do not conform to known anatomical pathways and physiological mechanisms. It has sometimes been stated that the presenting symptoms tend to reflect the patient's own understanding of anatomy and that the less medical knowledge a person has, the more implausible are the presenting symptoms.[7] However, no systematic studies have yet been performed to substantiate this statement.

Causes[edit]

The original theory by the Ancient Egyptians, the condition was thought to affect only females, and was considered to be due to spontaneous movement in the uterus.

In Greek Mythology, hysteria is considered to be the original psychiatric condition. The suggested treatment was orgasms. They believed that the condition was caused by inadequate sexual relations, which led to the uterus producing toxins and moving around the body.[8]

Freud's model[2] suggested that the emotional charge of painful experiences would be consciously repressed as a way of managing the pain, but this emotional charge would be somehow "converted" into the neurological symptoms. Freud later argued that the repressed experiences were of a sexual nature.[9] As Peter Halligan comments, conversion has 'the doubtful distinction among psychiatric diagnoses of still invoking Freudian mechanisms'.[10]

Janet, the other great theoretician of hysteria, argued that symptoms arose through the power of suggestion, acting on a personality vulnerable to dissociation.[11] In this hypothetical process, the subject's experience of their leg, for example, is split-off from the rest of their consciousness, resulting in paralysis or numbness in that leg. Later authors have attempted to combine elements of these models, but none of them has a firm empirical basis.[12]

Some support for the Freudian model comes from findings of high rates of childhood sexual abuse in conversion patients.[13] Support for the dissociation model comes from studies showing heightened suggestibility in conversion patients,.[14]

Much recent work has been done to identify the underlying causes of the conversion and related disorders as well as to better understand why conversion and hysteria appear more commonly in women. Current theoreticians tend to believe that there is no single cause for these disorders. Instead, the emphasis tends to be on the individual understanding of the patient as well as on a variety of therapeutic techniques. While the exact causes of conversion disorder are unknown, symptoms of the disorder seem to relate to the occurrence of a psychological conflict or stressor. In some cases, the onset of the disorder correlates to a traumatic or stressful event. There are also certain populations that are considered at risk for conversion disorder including people suffering from a medical illness or condition, people with personality disorder, and individuals with dissociative identity disorder.[6]

There has been much recent interest in functional neuroimaging in conversion. As researchers identify the mechanisms which underlie conversion symptoms it is hoped these will allow the development of a neuropsychological model. A number of such studies have been performed, including some which suggest that blood flow in patients' brains may be abnormal while they are unwell. These have all been too small to be confident of the generalisability of their findings, however, so no neuropsychological model has been clearly established.

An evolutionary psychology explanation for conversion disorder is that the symptom may have been evolutionarily advantageous during warfare. A non-combatant with these symptoms signals non-verbally, possibly to someone speaking a different language, that she or he is not dangerous as a combatant and also may be carrying some form of dangerous infectious disease. This can explain that conversion disorder may develop following a threatening situation, that there may be a group effect with many people simultaneously developing similar symptoms (as in mass psychogenic illness), and the gender difference in prevalence.[15]

The Lacanian model accepts conversion as common phenomenon inherent in specific psychical structure. The higher prevalence of it among women is based on somewhat different intrapsychic relation to the body compared to that of typical males. This allows the formation of conversion symptoms.[16]

Exclusion of neurological disease[edit]

Conversion disorder presents with symptoms that typically resemble a neurological disorder such as stroke, multiple sclerosis, epilepsy or hypokalemic periodic paralysis. The neurologist must carefully exclude neurological disease, through examination and appropriate investigations.[17] However, it is not uncommon for patients with neurological disease to also have conversion disorder.[18]

In excluding neurological disease, the neurologist has traditionally relied partly on the presence of positive signs of conversion disorder — certain aspects of the presentation that were thought to be rare in neurological disease, but common in conversion. The validity of many of these signs has been questioned, however, by a study showing that they also occurred in neurological disease.[19] One such symptom, for example, is La belle indifférence, described in DSM-IV as "a relative lack of concern about the nature or implications of the symptoms". In a later study no evidence was found that patients with "functional" symptoms are any more likely to exhibit this than patients with a confirmed organic disease.[20] In the DSM-V, 'la belle indifférence was removed as a diagnostic criteria.

Another feature thought to be important was that symptoms would tend to be more severe on the non-dominant (usually left) side; there were a variety of theories such as the relative involvement of cerebral hemispheres in emotional processing, or more simply just that it was "easier" to live with a functional deficit on the non-dominant side. However, a literature review of 121 studies established that this was not true, with publication bias the most likely explanation for this commonly held view.[21] Although agitation is often assumed to be a positive sign of conversion disorder, release of epinephrine is a well-demonstrated cause of paralysis from hypokalemic periodic paralysis.[22]

Misdiagnosis does sometimes occur. In a highly influential[23] study from the 1960s, Eliot Slater demonstrated that misdiagnoses had occurred in one third of his 112 patients with conversion disorder.[24] Later authors have argued that the paper was flawed, however,[25][26] and a meta-analysis has shown that misdiagnosis rates since that paper are around 4%, the same as for other neurological diseases.[17]

Exclusion of feigning[edit]

Conversion disorder is unique in DSM-5 in explicitly requiring the exclusion of deliberate feigning. Unfortunately, this is only likely to be demonstrable where the patient confesses, or is "caught out" in a broader deception, such as a false identity.[27] One neuroimaging study suggested that feigning may be distinguished from conversion by the pattern of frontal lobe activation;[28] however, this is a piece of research, rather than a clinical technique. True rates of feigning in medicine remain unknown. However, it is believed that feigning of conversion disorder is no more likely than of other medical conditions.

Psychological mechanism[edit]

The psychological mechanism can be the most difficult aspect of the conversion diagnosis. Even if there is a clear antecedent trauma or other possible psychological trigger, it is still not clear exactly how this gives rise to the symptoms observed. Patients with medically unexplained neurological symptoms may not have any psychological stressor, thus the term 'Functional Neurological Disorder' was used in the DSM-V as opposed to 'Conversion Disorder', and the need for a psychological trigger was removed.

Treatment[edit]

There are a number of different treatments that are available to treat and manage conversion syndrome. Treatments for conversion syndrome include hypnosis, psychotherapy, physical therapy, stress management, and transcranial magnetic stimulation. Treatment plans will consider duration and presentation of symptoms and may include one or multiple of the above treatments.[29] This may include the following:[30]

  1. Explanation. This must be clear and coherent as attributing physical symptoms to a psychological cause is not accepted by many educated people in western cultures. It must emphasize the genuineness of the condition, that it is common, potentially reversible and does not mean that the sufferer is psychotic. Taking an etiologically neutral stance by describing the symptoms as functional may be helpful but further studies are required. Ideally, the patient should be followed up neurologically for a while to ensure that the diagnosis has been understood.
  2. Physiotherapy where appropriate;
  3. Occupational Therapy to maintain autonomy in activities of daily living;[31]
  4. Treatment of comorbid depression or anxiety if present.

There is little evidence-based treatment of conversion disorder.[32] Other treatments such as cognitive behavioral therapy, hypnosis, EMDR, and psychodynamic psychotherapy, EEG brain biofeedback need further trials. Psychoanalytic treatment may possibly be helpful.[33] However, most studies assessing the efficacy of these treatments are of poor quality and larger, better controlled studies are urgently needed. Cognitive Behavioural Therapy is the most common treatment, however boasts a mere 13% improvement rate.

Prognosis[edit]

Empirical studies have found that the prognosis for conversion disorder varies widely, with some cases resolving in weeks, and others enduring for years or decades.[34][35]

Epidemiology[edit]

Frequency[edit]

Information on the frequency of conversion disorder in the West is limited, in part due to the complexities of the diagnostic process. In neurology clinics, the reported prevalence of unexplained symptoms among new patients is very high (between 30 and 60%)[36][37][38] However, diagnosis of conversion typically requires an additional psychiatric evaluation, and since few patients will see a psychiatrist[39] it is unclear what proportion of the unexplained symptoms are actually due to conversion. Large scale psychiatric registers in the US and Iceland found incidence rates of 22 and 11 newly diagnosed cases per 100,000 person-years, respectively,[40]

Culture[edit]

Although it is often thought that the frequency of conversion may be higher outside of the West, perhaps in relation to cultural and medical attitudes, evidence of this is limited.[3] A community survey of urban Turkey found a prevalence of 5.6%.[41] Many authors have found occurrence of conversion to be more frequent in rural, lower socio-economic groups, where technological investigation of patients is limited and individuals may be less knowledgeable about medical and psychological concepts.[40][42][43]

Gender[edit]

Historically, the concept of 'hysteria' was originally understood to be a condition exclusively affecting women, though the concept was eventually extended to men. In recent surveys of conversion disorder (formerly classified as "hysterical neurosis, conversion type"),[36][41] females predominate, with between 2 and 6 female patients for every male.

Age[edit]

Conversion disorder may present at any age but is rare in children younger than 10 years or in the elderly. Studies suggest a peak onset in the mid-to-late 30s.[36][40][41]

History[edit]

Conversion disorder has been described as early as the second millennium BC.[8]

In the 19th century, physicians such as Silas Weir Mitchell in the US and Paul Briquet (fr) and Jean-Martin Charcot in France developed ideas about patients sharing unexplained neurological symptoms. Charcot specialised in treating patients who were suffering from a variety of unexplained physical symptoms including paralysis, contractures (muscles which contract and cannot be relaxed) and seizures. Some of these patients sporadically and compulsively adopted a bizarre posture (christened arc-de-cercle) in which they arched their body backwards until they were supported only by their head and their heels.

The term "conversion disorder" originated with Freud. He viewed these apparently neurological symptoms as a result of the conversion of intrapsychic distress into physical symptoms. This distress was thought to cause the brain to unconsciously disable or impair a bodily function as a side effect of the original repression, which served to relieve the patient's anxiety.[44] However, some have claimed that patients do remain distressed by their symptoms in the long term[25]

It has also been suggested that at least some of the classic psychoanalytic cases of hysteria, such as "Anna O.",[45] may actually have suffered from organic illness. In fact, in Studies On Hysteria in which Breuer's Anna O. case was first presented, Freud wrote this: "Others of the patient's symptoms were not of a hysterical nature at all. This is true, for example, of the neck cramps, which I consider a modified version of migraine and which as such are not to be classified as a neurosis but as an organic disorder. Hysterical symptoms, however, regularly become attached to these." Freud believed that all hysterical symptoms ultimately have some organic components.[46]

See also[edit]

References[edit]

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  4. ^ International Statistical Classification of Diseases and Related Health Problems, 10th Revision.  F44.9
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  44. ^ Breuer and Freud, "Studies in Hysteria", 1895
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  46. ^ ( Breuer and Freud, *Studies on Hysteria* Basic Books, Inc. 2000, pg.96).