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In molecular biology, copines is a name for the group of human proteins that includes members such as CPNE1, CPNE4, CPNE6, and CPNE8.[1] These are highly conserved, calcium-dependent membrane proteins found in a variety of eukaryotes.[2] The domain structure of these proteins suggests that they may have a role in membrane trafficking in some prokaryotes as well as eukaryotes.[3]


  1. ^ "copine family". UniProtKB. Retrieved 28 March 2013. 
  2. ^ Damer, Cynthia K; Marina Bayeva; Emily S Hahn; Javier Rivera; Catherine I Socec (2005). "Copine A, a calcium-dependent membrane-binding protein, transiently localizes to the plasma membrane and intracellular vacuoles in Dictyostelium". BMC Cell Biology. 6: 46. doi:10.1186/1471-2121-6-46. Retrieved 28 March 2013. 
  3. ^ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem. 273 (3): 1393–402. PMID 9430674. doi:10.1074/jbc.273.3.1393.