Copper type II ascorbate-dependent monooxygenase

Copper type II ascorbate-dependent monooxygenase, N-terminal domain
reduced peptidylglycine alpha-hydroxylating monooxygenase in a new crystal form
Identifiers
Symbol	Cu2_monooxygen
Pfam	PF01082
InterPro	IPR000323
PROSITE	PDOC00080
SCOP2	1phm / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Copper type II ascorbate-dependent monooxygenase, C-terminal domain
reduced peptidylglycine alpha-hydroxylating monooxygenase in a new crystal form
Identifiers
Symbol	Cu2_monoox_C
Pfam	PF03712
PROSITE	PDOC00080
SCOP2	1phm / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the copper type II ascorbate-dependent monooxygenases are a class of enzymes that require copper as a cofactor and which use ascorbate as an electron donor. This family contains two related enzymes, dopamine beta-monooxygenase EC 1.14.17.1 and peptidylglycine alpha-amidating monooxygenase EC 1.14.17.3. There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.

References

This article incorporates text from the public domain Pfam and InterPro: IPR000323

External links

• Eukaryotic Linear Motif resource motif class MOD_Cter_Amidation