In October 2014, a collaboration of the Swiss Federal Institute of Technology, Switzerland and the University of Bonn, Germany reported, that they had identified a new antimicrobial peptide, excreted from the inky cap mushroom (Coprinopsis cinereacopsin) grown on horse dung.
Mechanism of action
Copsin is an inhibitor of cell wall synthesis by binding to Lipid II. It was reported to be potent in the petri dish against Gram positive bacteria which have a cell wall, including Enterococcus faecium and Listeria monocytogenes. It is not active against bacteria with an outer membrane, such as gram negative bacteria.
The "exceptionally stable protein", can be boiled at 100 degrees Celsius, can be mixed in strong acid for hours, and can also survive very aggressive enzymes, " remaining completely active". It is considered for use in the food industry for food preservation.
- Essig A, Hofmann D, Münch D, et al. (12 December 2014). "Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis". J Biol Chem. 289 (50): 34953–64. doi:10.1074/jbc.M114.599878. PMC . PMID 25342741.
- "Copsin antibiotic found in mushroom that grows on horse dung". CBC News. Thomson Reuters. 12 December 2014. Retrieved 17 March 2015.
- Franzoi, Marco; van Heuvel, Yasemin; Thomann, Susanne; Schürch, Nadia; Kallio, Pauli T.; Venier, Paola; Essig, Andreas (2017-09-19). "Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin". Biochemistry. 56 (37): 4992–5001. doi:10.1021/acs.biochem.7b00697. ISSN 0006-2960.