Corneal abrasion

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Corneal abrasion
Human cornea with abrasion highlighted by fluorescein staining.jpg
A corneal abrasion after staining with fluorescein, it is the green mark on the eye.
SpecialtyEmergency medicine
SymptomsEye pain, light sensitivity[1]
Usual onsetRapid[2]
DurationLess than 3 days[1]
CausesMinor trauma, contact len use[1]
Diagnostic methodSlit lamp exam[1]
Differential diagnosisCorneal ulcer, globe rupture[1]
PreventionEye protection[1]
Frequency3 per 1,000 per year (United States)[1]

Corneal abrasion is a scratch to the surface of the cornea of the eye.[3] Symptoms include pain, redness, light sensitivity, and a feeling like a foreign body is in the eye.[1] Most people recover completely within three days.[1]

Most cases are due to minor trauma to the eye such as that which can occur with contact lens use or from fingernails.[1] About 25% of cases occur at work.[1] Diagnosis is often by slit lamp examination after fluorescein dye has been applied.[1] More significant injuries like a corneal ulcer, globe rupture, recurrent erosion syndrome, and a foreign body within the eye should be ruled out.[1]

Prevention includes the use of eye protection.[1] Treatment is typically with antibiotic ointment.[1] In those who wear contact lenses a fluoroquinolone antibiotic is often recommended.[1] Paracetamol (acetaminophen), NSAIDs, and eye drops such as cyclopentolate that paralysis the pupil can help with pain.[1] Evidence does not support the usefulness of eye patching for those with simple abrasions.[4]

About 3 per 1,000 people are affected a year in the United States.[1] Males are more often affected than females.[1] The typical age group affected is those in their 20s and 30s.[1] Complications can include bacterial keratitis, corneal ulcer, and iritis.[1] Complications may occur in up to 8% of people.[5]

Signs and symptoms[edit]

Signs and symptoms of corneal abrasion include pain, trouble with bright lights, a foreign-body sensation, excessive squinting, and reflex production of tears. Signs include epithelial defects and edema, and often redness of the eye. The vision may be blurred, both from any swelling of the cornea and from excess tears. Crusty buildup from excess tears may also be present.


Complications are the exception rather than the rule from simple corneal abrasions. It is important that any foreign body be identified and removed, especially if containing iron as rusting will occur.

Occasionally the healed epithelium may be poorly adherent to the underlying basement membrane in which case it may detach at intervals giving rise to recurrent corneal erosions.


Corneal abrasions are generally a result of trauma to the surface of the eye. Common causes include being poked by a finger, walking into a tree branch, and wearing old contact lenses.[citation needed] A foreign body in the eye may also cause a scratch if the eye is rubbed.

Injuries can also be incurred by "hard" or "soft" contact lenses that have been left in too long. Damage may result when the lenses are removed, rather than when the lens is still in contact with the eye. In addition, if the cornea becomes excessively dry, it may become more brittle and easily damaged by movement across the surface. Soft contact lens wear overnight has been extensively linked to gram negative keratitis (infection of the cornea) particularly by a bacterium known as Pseudomonas aeruginosa which forms in the eye's biofilm as a result of extended soft contact lens wear. When a corneal abrasion occurs either from the contact lens itself or another source, the injured cornea is much more susceptible to this type of bacterial infection than a non-contact lens user's would be. This is an optical emergency as it is sight (in some cases eye) threatening. Contact lens wearers who present with corneal abrasions should never be pressure patched because it has been shown through clinical studies that patching creates a warm, moist dark environment that can cause the cornea to become infected or cause an existing infection to be greatly accelerated on its destructive path.

Corneal abrasions are also a common and recurrent feature in people who suffer specific types of corneal dystrophy, such as lattice corneal dystrophy. Lattice dystrophy gets its name from an accumulation of amyloid deposits, or abnormal protein fibers, throughout the middle and anterior stroma. During an eye examination, the doctor sees these deposits in the stroma as clear, comma-shaped overlapping dots and branching filaments, creating a lattice effect. Over time, the lattice lines will grow opaque and involve more of the stroma. They will also gradually converge, giving the cornea a cloudiness that may also reduce vision. In some people, these abnormal protein fibers can accumulate under the cornea's outer layer—the epithelium. This can cause erosion of the epithelium. This condition is known as recurrent epithelial erosion. These erosions: (1) Alter the cornea's normal curvature, resulting in temporary vision problems; and (2) Expose the nerves that line the cornea, causing severe pain. Even the involuntary act of blinking can be painful.


Although corneal abrasions may be seen with ophthalmoscopes, slit lamp microscopes provide higher magnification which allow for a more thorough evaluation. To aid in viewing, a fluorescein stain that fills in the corneal defect and glows with a cobalt blue-light is generally instilled first.

A careful search should be made for any foreign body, in particular looking under the eyelids. Injury following use of hammers or power-tools should always raise the possibility of a penetrating foreign body into the eye, for which urgent ophthalmology opinion should be sought.



Topical antibiotics may be reasonable.[6]

One review has found that eye drops to numb the surface of the eye such as tetracaine improve pain; however, their safety is unclear.[7] Another review did not find evidence of benefit and concluded there was not enough data on safety.[8]

NSAID eye drops are also useful.[9] A 2000 review found no good evidence to support medications that paralyze the iris.[10] A 2017 review did not find evidence to suggest that topical NSAIDs would significantly reduce pain over standard-of-care treatments, but did find that NSAIDs could be associated with people using fewer pain medications by mouth.[11]


A meta-analysis found evidence that does not support the use of patching.[4]

Recurrent disease[edit]

There is not good evidence for the treatment of recurrent disease.[12][needs update] Special content lenses do not appear very useful.[12]

Other animals[edit]


  1. ^ a b c d e f g h i j k l m n o p q r s t u Ahmed, Faheem; House, Robert James; Feldman, Brad Hal (1 September 2015). "Corneal Abrasions and Corneal Foreign Bodies". Primary Care. 42 (3): 363–375. doi:10.1016/j.pop.2015.05.004. ISSN 1558-299X. PMID 26319343.
  2. ^ FNP-C, Maria T. Codina Leik, MSN, APRN, BC (2013). Family Nurse Practitioner Certification Intensive Review: Fast Facts and Practice Questions, Second Edition (2 ed.). Springer Publishing Company. p. 112. ISBN 9780826134257. Archived from the original on 2016-11-07.
  3. ^ "Corneal Abrasion". National Eye Institute. Archived from the original on 2016-11-07. Retrieved 2016-11-06.
  4. ^ a b Lim, CH; Turner, A; Lim, BX (26 July 2016). "Patching for corneal abrasion". The Cochrane Database of Systematic Reviews. 7: CD004764. doi:10.1002/14651858.CD004764.pub3. PMID 27457359.
  5. ^ Smolin, Gilbert; Foster, Charles Stephen; Azar, Dimitri T.; Dohlman, Claes H. (2005). Smolin and Thoft's The Cornea: Scientific Foundations and Clinical Practice. Lippincott Williams & Wilkins. p. 798. ISBN 9780781742061. Archived from the original on 2016-11-07.
  6. ^ "UpToDate Inc".
  7. ^ Swaminathan, A; Otterness, K; Milne, K; Rezaie, S (14 August 2015). "The Safety of Topical Anesthetics in the Treatment of Corneal Abrasions: A Review". The Journal of emergency medicine. 49: 810–5. doi:10.1016/j.jemermed.2015.06.069. PMID 26281814.
  8. ^ Puls, HA; Cabrera, D; Murad, MH; Erwin, PJ; Bellolio, MF (12 October 2015). "Safety and Effectiveness of Topical Anesthetics in Corneal Abrasions: Systematic Review and Meta-Analysis". The Journal of emergency medicine. 49: 816–24. doi:10.1016/j.jemermed.2015.02.051. PMID 26472608.
  9. ^ Calder, LA; Balasubramanian, S; Fergusson, D (May 2005). "Topical nonsteroidal anti-inflammatory drugs for corneal abrasions: meta-analysis of randomized trials". Academic Emergency Medicine. 12 (5): 467–73. doi:10.1197/j.aem.2004.10.026. PMID 15860701.
  10. ^ "BestBets: Mydriatics in corneal abrasion". Archived from the original on 2008-09-02.
  11. ^ Wakai A, Lawrenson JG, Lawrenson AL, Wang Y, Brown MD, Quirke M, Ghandour O, McCormick R, Walsh CD, Amayem A, Lang E, Harrison N (2017). "Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions". Cochrane Database Syst Rev. 5: CD009781. doi:10.1002/14651858.CD009781.pub2. PMID 28516471.
  12. ^ a b Watson, SL; Lee, MH; Barker, NH (12 September 2012). "Interventions for recurrent corneal erosions". The Cochrane Database of Systematic Reviews. 9: CD001861. doi:10.1002/14651858.CD001861.pub3. PMID 22972054.

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External resources