Cornelia Catharina de Lange

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Cornelia Catharina de Lange (24 June 1871 – 28 January 1950) was a Dutch pediatrician. Cornelia de Lange syndrome is named after her.


Born in Alkmaar, De Lange graduated from the University of Amsterdam in 1897 and began her general practice.[1] However, because pediatrics did not exist as a specialty in the Netherlands, De Lange moved to Switzerland, where she worked in the children's hospital in Zurich under Oskar Wyss.[1] In the early 1900s De Lange became an acclaimed specialist and attained a position in Amsterdam’s Children’s Hospital.[1] De Lange worked in all aspects of pediatrics. During her 50 years of practice she collected multiple observations of pediatric disorders.[2] De Lange also became interested in congenital disorders and their pediatric relevance as theories on human genetics developed during the 1920s and 1930s.[2] In 1933, De Lange described what she called "typus degenerativus Amstelodamensis" (Amsterdam degeneration type) in two children, which became known Cornelia de Lange syndrome.[1]


  1. ^ a b c d "History of the CdLS Foundation". CdLS Foundation. Retrieved 18 June 2015. 
  2. ^ a b De Knecht-van Eekelen, Annemarie; Hennekam, Raoul C. M. (1994). "Historical study: Cornelia C. de Lange (1871–1950)—a pioneer in clinical genetics". American Journal of Medical Genetics. 52 (3): 257–266. doi:10.1002/ajmg.1320520302. PMID 7810555. Retrieved 18 June 2015.