Corneodesmosin

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CDSN
Identifiers
AliasesCDSN, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
External IDsOMIM: 602593 HomoloGene: 48005 GeneCards: CDSN
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CDSN
Genomic location for CDSN
Band6p21.33Start31,115,087 bp[1]
End31,120,446 bp[1]
RNA expression pattern
PBB GE CDSN 206192 at fs.png

PBB GE CDSN 206193 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001264

n/a

RefSeq (protein)

NP_001255

n/a

Location (UCSC)Chr 6: 31.12 – 31.12 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.[3][4][5]

This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.[5]

See also[edit]

References[edit]

  1. ^ a b c ENSG00000206460, ENSG00000237123, ENSG00000237114, ENSG00000204539, ENSG00000237165 GRCh38: Ensembl release 89: ENSG00000137197, ENSG00000206460, ENSG00000237123, ENSG00000237114, ENSG00000204539, ENSG00000237165 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G (Jan 1998). "Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes". J Biol Chem. 272 (50): 31770–6. doi:10.1074/jbc.272.50.31770. PMID 9395522.
  4. ^ Zhou Y, Chaplin DD (Nov 1993). "Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation". Proc Natl Acad Sci U S A. 90 (20): 9470–4. doi:10.1073/pnas.90.20.9470. PMC 47590. PMID 8415725.
  5. ^ a b "Entrez Gene: CDSN corneodesmosin".

Further reading[edit]