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COVID-19 vaccine

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How COVID-19 vaccines work. The video shows the process of vaccination, from injection with RNA or viral vector vaccines, to uptake and translation, and on to immune system stimulation and effect.
Map showing share of population fully vaccinated against COVID-19 relative to a country's total population
Map of countries by approval status
  Approved for general use, mass vaccination underway
  EUA (or equivalent) granted, mass vaccination underway
  EUA granted, limited vaccination
  Approved for general use, mass vaccination planned
  EUA granted, mass vaccination planned
  EUA pending
  No data available
COVID-19 vaccine doses administered by continent as of Oct 11, 2021. For vaccines that require multiple doses, each individual dose is counted. As the same person may receive more than one dose, the number of doses can be higher than the number of people in the population.

A COVID‑19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 (COVID‑19). Prior to the COVID‑19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated the development of various vaccine platforms during early 2020.[1] The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic, often severe illness.[2] On 10 January 2020, the SARS-CoV-2 genetic sequence data was shared through GISAID, and by 19 March, the global pharmaceutical industry announced a major commitment to address COVID-19.[3] The COVID‑19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19.[4]

Many countries have implemented phased distribution plans that prioritize those at highest risk of complications, such as the elderly, and those at high risk of exposure and transmission, such as healthcare workers.[5]

As of 25 November 2021, 7.85 billion doses of COVID‑19 vaccines have been administered worldwide based on official reports from national public health agencies.[6] By December 2020, more than 10 billion vaccine doses had been preordered by countries,[7] with about half of the doses purchased by high-income countries comprising 14% of the world's population.[8]

Background

A US airman receiving a COVID-19 vaccine, December 2020

Prior to COVID‑19, a vaccine for an infectious disease had never been produced in less than several years – and no vaccine existed for preventing a coronavirus infection in humans.[9] However, vaccines have been produced against several animal diseases caused by coronaviruses, including (as of 2003) infectious bronchitis virus in birds, canine coronavirus, and feline coronavirus.[10] Previous projects to develop vaccines for viruses in the family Coronaviridae that affect humans have been aimed at severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Vaccines against SARS[11] and MERS[12] have been tested in non-human animals.

According to studies published in 2005 and 2006, the identification and development of novel vaccines and medicines to treat SARS was a priority for governments and public health agencies around the world at that time.[13][14][15] There is no cure or protective vaccine proven to be safe and effective against SARS in humans.[16][17] There is also no proven vaccine against MERS.[18] When MERS became prevalent, it was believed that existing SARS research might provide a useful template for developing vaccines and therapeutics against a MERS-CoV infection.[16][19] As of March 2020, there was one (DNA-based) MERS vaccine which completed Phase I clinical trials in humans,[20] and three others in progress, all being viral-vectored vaccines: two adenoviral-vectored (ChAdOx1-MERS, BVRS-GamVac) and one MVA-vectored (MVA-MERS-S).[21]

Vaccines that use an inactive or weakened virus that has been grown in eggs typically take more than a decade to develop.[22][23] In contrast, mRNA is a molecule that can be made quickly, and research on mRNA to fight diseases was begun decades before the COVID-19 pandemic by scientists such as Drew Weissman and Katalin Karikó, who tested on mice. Moderna began human testing of an mRNA vaccine in 2015.[22] Viral vector vaccines were also developed for the COVID-19 pandemic after the technology was previously cleared for Ebola.[22]

As multiple COVID-19 vaccines have been authorized or licensed for use, real-world vaccine effectiveness (RWE) is being assessed using case control and observational studies.[24] A study is investigating the long-lasting protection against SARS-CoV-2 provided by the mRNA vaccines.[25] On 10 August 2021, a study showed that the full vaccination coverage rate is correlated inversely to the SARS-CoV-2 delta variant mutation frequency in 16 countries (R-squared=0.878).[26]

Formulation

As of September 2020, eleven of the vaccine candidates in clinical development use adjuvants to enhance immunogenicity.[27] An immunological adjuvant is a substance formulated with a vaccine to elevate the immune response to an antigen, such as the COVID‑19 virus or influenza virus.[28] Specifically, an adjuvant may be used in formulating a COVID‑19 vaccine candidate to boost its immunogenicity and efficacy to reduce or prevent COVID‑19 infection in vaccinated individuals.[28][29] Adjuvants used in COVID‑19 vaccine formulation may be particularly effective for technologies using the inactivated COVID‑19 virus and recombinant protein-based or vector-based vaccines.[29] Aluminum salts, known as "alum", were the first adjuvant used for licensed vaccines, and are the adjuvant of choice in some 80% of adjuvanted vaccines.[29] The alum adjuvant initiates diverse molecular and cellular mechanisms to enhance immunogenicity, including release of proinflammatory cytokines.[28][29]

Sequencing

In November 2021, the full nucleotide sequences of the AstraZeneca and Pfizer/BioNTech vaccines were released by the UK Medicines and Healthcare Products Regulatory Agency, in response to a Freedom of Information request.[30][31]

Clinical research

COVID-19 vaccine clinical research uses clinical research to establish the characteristics of COVID-19 vaccines. These characteristics include efficacy, effectiveness and safety. 24 vaccines are authorized for use by national governments, including seven approved for emergency or full use by at least one WHO-recognised stringent regulatory authority; while five are in Phase IV. 204 vaccines are undergoing clinical trials that have yet to be authorized. Nine clinical trials consider heterologous vaccination courses.

Twenty five vaccines are authorized by at least one national regulatory authority for public use: one DNA vaccine (ZyCoV-D) two RNA vaccines (Pfizer–BioNTech and Moderna), ten conventional inactivated vaccines (Chinese Academy of Medical Sciences, CoronaVac, Covaxin, CoviVac, COVIran Barekat, FAKHRAVAC, Minhai-Kangtai, QazVac, Sinopharm BIBP and WIBP), five viral vector vaccines (Sputnik Light, Sputnik V, Oxford–AstraZeneca, Convidecia, and Janssen), and seven subunit vaccines (Abdala, COVAX-19, EpiVacCorona, MVC-COV1901, Soberana 02, Novavax, and ZF2001).[32][33] As of July 2021, 330 vaccine candidates were in various stages of development, with 102 in clinical research, including 30 in Phase I trials, 30 in Phase I–II trials, 25 in Phase III trials, and 8 in Phase IV development.[32]

Post-vaccination complications

Post-vaccination embolic and thrombotic events, also termed vaccine-induced prothrombotic immune thrombocytopenia (VIPIT),[34] vaccine-induced immune thrombotic thrombocytopenia (VITT),[35][36] or thrombosis with thrombocytopenia syndrome (TTS)[37] are rare types of blood clotting syndromes that were initially observed in a number of people who had previously received the Oxford–AstraZeneca COVID-19 vaccine (AZD1222)[a] during the COVID-19 pandemic.[34][41] It was subsequently also described in the Janssen COVID-19 vaccine (Johnson & Johnson) leading to suspension of its use until its safety had been reassessed.[42]

In April 2021, AstraZeneca and the EMA updated their information for healthcare professionals about AZD1222, saying it was "considered plausible" that there was a causal relationship between the vaccination and the occurrence of thrombosis in combination with thrombocytopenia and that, "although such adverse reactions are very rare, they exceeded what would be expected in the general population".[41][43][44][45]

Vaccine types

Conceptual diagram showing three vaccine types for forming SARS‑CoV‑2 proteins to prompt an immune response: (1) RNA vaccine, (2) subunit vaccine, (3) viral vector vaccine
Vaccine platforms being employed for SARS-CoV-2. Whole virus vaccines include both attenuated and inactivated forms of the virus. Protein and peptide subunit vaccines are usually combined with an adjuvant in order to enhance immunogenicity. The main emphasis in SARS-CoV-2 vaccine development has been on using the whole spike protein in its trimeric form, or components of it, such as the RBD region. Multiple non-replicating viral vector vaccines have been developed, particularly focused on adenovirus, while there has been less emphasis on the replicating viral vector constructs.[46]

At least nine different technology platforms are under research and development to create an effective vaccine against COVID‑19.[27][47] Most of the platforms of vaccine candidates in clinical trials are focused on the coronavirus spike protein (S protein) and its variants as the primary antigen of COVID‑19 infection,[27] since the S protein triggers strong B-cell and T-cell immune responses.[48][49] However, other coronavirus proteins are also being investigated for vaccine development, like the nucleocapsid, because they also induce a robust T-cell response and their genes are more conserved and recombine less frequently (compared to Spike).[49][50][51]

Platforms being developed in 2020 involved nucleic acid technologies (nucleoside-modified messenger RNA and DNA), non-replicating viral vectors, peptides, recombinant proteins, live attenuated viruses, and inactivated viruses.[9][27][52][53]

Many vaccine technologies being developed for COVID‑19 are not like vaccines already in use to prevent influenza, but rather are using "next-generation" strategies for precise targeting of COVID‑19 infection mechanisms.[27][52][53] Several of the synthetic vaccines use a 2P mutation to lock the spike protein into its prefusion configuration, stimulating an adaptive immune response to the virus before it attaches to a human cell.[54] Vaccine platforms in development may improve flexibility for antigen manipulation, and effectiveness for targeting mechanisms of COVID‑19 infection in susceptible population subgroups, such as healthcare workers, the elderly, children, pregnant women, and people with weakened immune systems.[27][52]

mRNA vaccines

Diagram of the operation of an RNA vaccine. Messenger RNA contained in the vaccine enters cells and is translated into foreign proteins, which trigger an immune response.

Several COVID-19 vaccines, including the Pfizer–BioNTech and Moderna vaccines, have been developed to use RNA to stimulate an immune response. When introduced into human tissue, the vaccine contains either self-replicating RNA or messenger RNA (mRNA), which both cause cells to express the SARS-CoV-2 spike protein. This teaches the body how to identify and destroy the corresponding pathogen. RNA vaccines often, but not always, use nucleoside-modified messenger RNA. The delivery of mRNA is achieved by a coformulation of the molecule into lipid nanoparticles which protect the RNA strands and help their absorption into the cells.[55][56][57][58]

RNA vaccines were the first COVID‑19 vaccines to be authorized in the United Kingdom, the United States and the European Union.[59][60] Authorized vaccines of this type are the Pfizer–BioNTech[61][62][63] and Moderna vaccines.[64][65] The CVnCoV RNA vaccine from CureVac failed in clinical trails.[66]

Severe allergic reactions are rare. In December 2020, 1,893,360 first doses of Pfizer–BioNTech COVID‑19 vaccine administration resulted in 175 cases of severe allergic reaction, of which 21 were anaphylaxis.[67] For 4,041,396 Moderna COVID‑19 vaccine dose administrations in December 2020 and January 2021, only ten cases of anaphylaxis were reported.[67] Lipid nanoparticles (LNPs) were most likely responsible for the allergic reactions.[67]

Adenovirus vector vaccines

These vaccines are examples of non-replicating viral vector vaccines, using an adenovirus shell containing DNA that encodes a SARS‑CoV‑2 protein.[68][69] The viral vector-based vaccines against COVID‑19 are non-replicating, meaning that they do not make new virus particles, but rather produce only the antigen which elicits a systemic immune response.[68]

Authorized vaccines of this type are the Oxford–AstraZeneca COVID-19 vaccine,[70][71][72] the Sputnik V COVID-19 vaccine,[73] Convidecia, and the Janssen COVID-19 vaccine.[74][75]

Convidecia and the Janssen COVID-19 vaccine are both one-shot vaccines which offer less complicated logistics and can be stored under ordinary refrigeration for several months.[76][77]

Sputnik V uses Ad26 for its first dose, which is the same as Janssen's only dose, and Ad5 for the second dose, which is the same as Convidecia's only dose.[78]

On 11 August 2021, the developers of Sputnik V proposed, in view of the Delta case surge that Pfizer test the Ad26 component (termed its ‘Light’ version)[79] as a booster shot:

Delta cases surge in US & Israel shows mRNA vaccines need a heterogeneous booster to strengthen & prolong immune response. #SputnikV pioneered mix&match approach, combo trials & showed 83.1% efficacy vs Delta. Today RDIF offers Pfizer to start trial with Sputnik Light as booster.[80]

Inactivated virus vaccines

Inactivated vaccines consist of virus particles that have been grown in culture and then are killed using a method such as heat or formaldehyde to lose disease producing capacity, while still stimulating an immune response.[81]

Authorized vaccines of this type are the Chinese CoronaVac[82][83][84] and the Sinopharm BIBP[85] and WIBP vaccines; the Indian Covaxin; later this year the Russian CoviVac;[86] the Kazakhstani vaccine QazVac;[87] and the Iranian COVIran Barekat.[88] Vaccines in clinical trials include the Valneva COVID-19 vaccine.[89][unreliable source?][90]

Subunit vaccines

Subunit vaccines present one or more antigens without introducing whole pathogen particles. The antigens involved are often protein subunits, but can be any molecule that is a fragment of the pathogen.[91]

The three authorized vaccines of this type are the peptide vaccine EpiVacCorona,[92] ZF2001,[47] and MVC-COV1901.[93] Vaccines with pending authorizations include the Novavax COVID-19 vaccine,[94] Soberana 02 (a conjugate vaccine), and the Sanofi–GSK vaccine.

The V451 vaccine was previously in clinical trials, which were terminated because it was found that the vaccine may potentially cause incorrect results for subsequent HIV testing.[95][96]

Intranasal

Intranasal vaccines target mucosal immunity in the nasal mucosa which is a portal for viral entrance to the body.[97][98] These vaccines are designed to stimulate nasal immune factors, such as IgA.[97] In addition to inhibiting the virus, nasal vaccines provide ease of administration because no needles (and the accompanying needle phobia) are involved.[98][99] Nasal vaccines have been approved for other infections, such as influenza.[98][99] As of 2021, only one nasal vaccine, Flumist (USA); Fluenz Tetra (European Union), had been authorized in the United States and Europe for use as an influenza vaccine.[99][100][clarification needed]

Other types

Additional types of vaccines that are in clinical trials include virus-like particle vaccines, multiple DNA plasmid vaccines,[101][102][103][104][105][106] at least two lentivirus vector vaccines,[107][108] a conjugate vaccine, and a vesicular stomatitis virus displaying the SARS‑CoV‑2 spike protein.[109]

Scientists investigated whether existing vaccines for unrelated conditions could prime the immune system and lessen the severity of COVID‑19 infection.[110] There is experimental evidence that the BCG vaccine for tuberculosis has non-specific effects on the immune system, but no evidence that this vaccine is effective against COVID‑19.[111]

Planning and development

Since January 2020, vaccine development has been expedited via unprecedented collaboration in the multinational pharmaceutical industry and between governments.[27]

Multiple steps along the entire development path are evaluated, including:[9][112]

  • the level of acceptable toxicity of the vaccine (its safety),
  • targeting vulnerable populations,
  • the need for vaccine efficacy breakthroughs,
  • the duration of vaccination protection,
  • special delivery systems (such as oral or nasal, rather than by injection),
  • dose regimen,
  • stability and storage characteristics,
  • emergency use authorization before formal licensing,
  • optimal manufacturing for scaling to billions of doses, and
  • dissemination of the licensed vaccine.

Challenges

There have been several unique challenges with COVID‑19 vaccine development.

The urgency to create a vaccine for COVID‑19 led to compressed schedules that shortened the standard vaccine development timeline, in some cases combining clinical trial steps over months, a process typically conducted sequentially over several years.[113] Public health programs have been described as in "[a] race to vaccinate individuals" with the early wave vaccines.[114]

Timelines for conducting clinical research – normally a sequential process requiring years – are being compressed into safety, efficacy, and dosing trials running simultaneously over months, potentially compromising safety assurance.[113][115] As an example, Chinese vaccine developers and the government Chinese Center for Disease Control and Prevention began their efforts in January 2020,[116] and by March were pursuing numerous candidates on short timelines, with the goal to showcase Chinese technology strengths over those of the United States, and to reassure the Chinese people about the quality of vaccines produced in China.[113][117]

The rapid development and urgency of producing a vaccine for the COVID‑19 pandemic was expected to increase the risks and failure rate of delivering a safe, effective vaccine.[52][53][118] Additionally, research at universities is obstructed by physical distancing and closing of laboratories.[119][120]

Vaccines must progress through several phases of clinical trials to test for safety, immunogenicity, effectiveness, dose levels and adverse effects of the candidate vaccine.[121][122] Vaccine developers have to invest resources internationally to find enough participants for Phase II–III clinical trials when the virus has proved to be a "moving target" of changing transmission rates across and within countries, forcing companies to compete for trial participants.[123] Clinical trial organizers also may encounter people unwilling to be vaccinated due to vaccine hesitancy[124] or disbelief in the science of the vaccine technology and its ability to prevent infection.[125] As new vaccines are developed during the COVID‑19 pandemic, licensure of COVID‑19 vaccine candidates requires submission of a full dossier of information on development and manufacturing quality.[126][127][128]

Organizations

Internationally, the Access to COVID-19 Tools Accelerator is a G20 and World Health Organization (WHO) initiative announced in April 2020.[129][130] It is a cross-discipline support structure to enable partners to share resources and knowledge. It comprises four pillars, each managed by two to three collaborating partners: Vaccines (also called "COVAX"), Diagnostics, Therapeutics, and Health Systems Connector.[131] The WHO's April 2020 "R&D Blueprint (for the) novel Coronavirus" documented a "large, international, multi-site, individually randomized controlled clinical trial" to allow "the concurrent evaluation of the benefits and risks of each promising candidate vaccine within 3–6 months of it being made available for the trial." The WHO vaccine coalition will prioritize which vaccines should go into Phase II and III clinical trials, and determine harmonized Phase III protocols for all vaccines achieving the pivotal trial stage.[132]

National governments have also been involved in vaccine development. Canada announced funding of 96 projects for development and production of vaccines at Canadian companies and universities with plans to establish a "vaccine bank" that could be used if another coronavirus outbreak occurs,[133] and to support clinical trials and develop manufacturing and supply chains for vaccines.[134]

China provided low-rate loans to one vaccine developer through its central bank, and "quickly made land available for the company" to build production plants.[115] Three Chinese vaccine companies and research institutes are supported by the government for financing research, conducting clinical trials, and manufacturing.[135]

Great Britain formed a COVID‑19 vaccine task force in April 2020 to stimulate local efforts for accelerated development of a vaccine through collaborations of industry, universities, and government agencies. It encompassed every phase of development from research to manufacturing.[136]

In the United States, the Biomedical Advanced Research and Development Authority (BARDA), a federal agency funding disease-fighting technology, announced investments to support American COVID‑19 vaccine development, and manufacture of the most promising candidates.[115][137] In May 2020, the government announced funding for a fast-track program called Operation Warp Speed.[138][139] By March 2021, BARDA had funded an estimated $19.3 billion in COVID-19 vaccine development.[140]

Large pharmaceutical companies with experience in making vaccines at scale, including Johnson & Johnson, AstraZeneca, and GlaxoSmithKline (GSK), formed alliances with biotechnology companies, governments, and universities to accelerate progression towards effective vaccines.[115][113]

History

COVID‑19 vaccine research samples in a NIAID lab freezer (30 January 2020)

COVID-19's caused virus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), was isolated in late 2019.[141] Its genetic sequence was published on 11 January 2020, triggering an urgent international response to prepare for an outbreak and hasten development of a preventive COVID-19 vaccine.[142][143][144] Since 2020, vaccine development has been expedited via unprecedented collaboration in the multinational pharmaceutical industry and between governments.[145] By June 2020, tens of billions of dollars were invested by corporations, governments, international health organizations, and university research groups to develop dozens of vaccine candidates and prepare for global vaccination programs to immunize against COVID‑19 infection.[143][146][147][148] According to the Coalition for Epidemic Preparedness Innovations (CEPI), the geographic distribution of COVID‑19 vaccine development shows North American entities to have about 40% of the activity, compared to 30% in Asia and Australia, 26% in Europe, and a few projects in South America and Africa.[142][145]

In February 2020, the World Health Organization (WHO) said it did not expect a vaccine against SARS‑CoV‑2 to become available in less than 18 months.[149] Virologist Paul Offit commented that, in hindsight, the development of a safe and effective vaccine within 11 months was a remarkable feat.[150] The rapidly growing infection rate of COVID‑19 worldwide during 2020 stimulated international alliances and government efforts to urgently organize resources to make multiple vaccines on shortened timelines,[151] with four vaccine candidates entering human evaluation in March (see COVID-19 vaccine § Trial and authorization status).[142][152]

On 24 June 2020, China approved the CanSino vaccine for limited use in the military, and two inactivated virus vaccines for emergency use in high-risk occupations.[153] On 11 August 2020, Russia announced the approval of its Sputnik V vaccine for emergency use, though one month later only small amounts of the vaccine had been distributed for use outside of the phase 3 trial.[154]

The Pfizer–BioNTech partnership submitted an Emergency Use Authorization (EUA) request to the U.S. Food and Drug Administration (FDA) for the mRNA vaccine BNT162b2 (active ingredient tozinameran) on 20 November 2020.[155][156] On 2 December 2020, the United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) gave temporary regulatory approval for the Pfizer–BioNTech vaccine,[157][158] becoming the first country to approve the vaccine and the first country in the Western world to approve the use of any COVID‑19 vaccine.[159][160][161] As of 21 December 2020, many countries and the European Union[162] had authorized or approved the Pfizer–BioNTech COVID‑19 vaccine. Bahrain and the United Arab Emirates granted emergency marketing authorization for the Sinopharm BIBP vaccine.[163][164] On 11 December 2020, the FDA granted an EUA for the Pfizer–BioNTech COVID‑19 vaccine.[165] A week later, they granted an EUA for mRNA-1273 (active ingredient elasomeran), the Moderna vaccine.[166][167][168][169]

On 31 March 2021, the Russian government announced that they had registered the first COVID‑19 vaccine for animals.[170] Named Carnivac-Cov, it is an inactivated vaccine for carnivorous animals, including pets, aimed at preventing mutations that occur during the interspecies transmission of SARS-CoV-2.[171]

In June 2021, a report revealed that the UB-612 vaccine, developed by the US-based COVAXX, was a venture initiated for profits by the Blackwater founder Erik Prince. In a series of text messages to Paul Behrends, the close associate recruited for the COVAXX project, Prince described the profit-making possibilities in selling the COVID‑19 vaccines. COVAXX provided no data from the clinical trials on safety or efficacy. The responsibility of creating distribution networks was assigned to an Abu Dhabi-based entity, which was mentioned as "Windward Capital" on the COVAXX letterhead but was actually Windward Holdings. The firm's sole shareholder, which handled "professional, scientific and technical activities", was Erik Prince. In March 2021, COVAXX raised $1.35 billion in a private placement.[172]

Effectiveness

As of August 2021, studies reported that the COVID-19 vaccines available in the United States are "highly protective against severe illness, hospitalization, and death due to COVID-19".[173] In comparison with fully vaccinated people, the CDC reported that unvaccinated people were 5 times more likely to be infected, 10 times more likely to be hospitalized, and 11 times more likely to die.[174][175]

Another study found that unvaccinated people were six times more likely to test positive, 37 times more likely to be hospitalized, and 67 times more likely to die, compared to those who had been vaccinated.[176]

CDC reported that vaccine effectiveness fell from 91% against Alpha to 66% against Delta.[177] One expert stated that "those who are infected following vaccination are still not getting sick and not dying like was happening before vaccination."[178] By late August 2021 the Delta variant accounted for 99 percent of U.S. cases and was found to double the risk of severe illness and hospitalization for those not yet vaccinated.[179]

Adverse events

Serious adverse events associated with receipt of new vaccines targeting COVID-19 are of high interest to the public.[180] All vaccines that are administered via intramuscular injection, including COVID-19 vaccines, have side effects related to the mild trauma associated with the procedure and introduction of a foreign substance into the body.[181] These include soreness, redness, rash, and inflammation at the injection site. Other common side effects include fatigue, headache, myalgia (muscle pain), and arthralgia (joint pain) which generally resolve within a few days.[182]

One less-frequent side effect (that generally occurs in less than 1 in 1,000 people) is hypersensitivity (allergy) to one or more of the vaccine's ingredients, which in some rare cases may cause anaphylaxis.[183][184][185][186] Anaphylaxis has occurred in approximately 2 to 5 people per million vaccinated in the United States.[187] An increased risk of rare and potentially fatal thrombosis events have been associated in mainly younger female patients, following the administration of the Janssen (Johnson and Johnson)[188][189] and Oxford-AstraZenica COVID-19 vaccines.[189][190][191][192] There is no increased risk for thrombotic events after vaccination with mRNA COVID-19 vaccines like Pfizer and Moderna.[187]

Society and culture

Distribution

Note about table to the right: Number and percentage of people who have received at least one dose of a COVID-19 vaccine (unless noted otherwise). May include vaccination of non-citizens, which can push totals beyond 100% of the local population. Table is updated daily by a bot.[note 1]

Location Vaccinated[b] %[c]
World[d] 4,245,330,959 53.9%
China China 1,225,000,000 84.8%
India India 776,515,911 55.7%
European Union European Union 314,751,692 70.4%
United States United States[e] 231,367,686 68.8%
Brazil Brazil 162,436,791 75.9%
Indonesia Indonesia 137,505,204 49.8%
Japan Japan 99,653,851 79.1%
Pakistan Pakistan 79,587,750 35.3%
Mexico Mexico 76,164,064 58.5%
Vietnam Vietnam 67,824,005 69.1%
Russia Russia 65,248,010 44.7%
Germany Germany 59,018,263 70.3%
Bangladesh Bangladesh 56,704,586 34.1%
Iran Iran 56,653,947 66.6%
Turkey Turkey 56,144,078 66.0%
France France 51,813,455 76.7%
United Kingdom United Kingdom 50,852,133 74.6%
Philippines Philippines 48,111,411 43.7%
Thailand Thailand 47,233,526 67.5%
Italy Italy[f] 47,063,898 78.0%
South Korea South Korea 42,419,011 82.7%
Spain Spain 38,281,333 81.9%
Argentina Argentina 36,389,533 79.8%
Colombia Colombia 35,715,299 69.7%
Canada Canada 30,202,023 79.3%
Malaysia Malaysia 25,654,664 78.3%
Saudi Arabia Saudi Arabia 24,562,266 69.5%
Morocco Morocco 24,498,454 65.6%
Egypt Egypt 23,649,491 22.7%
Peru Peru 21,661,388 64.9%
Poland Poland 20,671,677 54.7%
Australia Australia 19,922,295 77.2%
Taiwan Taiwan 18,136,444 76.0%
South Africa South Africa 16,857,214 28.1%
Chile Chile 16,809,001 87.5%
Uzbekistan Uzbekistan 16,606,819 48.9%
Sri Lanka Sri Lanka 15,918,179 74.0%
Myanmar Myanmar 15,390,873 28.1%
Cambodia Cambodia 14,114,474 83.3%
Venezuela Venezuela 13,858,057 48.3%
Ecuador Ecuador 13,381,327 74.8%
Netherlands Netherlands 13,220,692 77.0%
Ukraine Ukraine 13,164,649 30.3%
Cuba Cuba 10,142,765 89.6%
United Arab Emirates United Arab Emirates 9,801,529 98.1%
Nepal Nepal 9,206,187 31.0%
Portugal Portugal 9,053,901 89.0%
Belgium Belgium 8,816,437 75.8%
Kazakhstan Kazakhstan 8,677,674 45.7%
Romania Romania 7,657,261 40.0%
Sweden Sweden 7,305,433 71.9%
Iraq Iraq 7,246,498 17.6%
Greece Greece 6,977,918 67.3%
Dominican Republic Dominican Republic 6,857,695 62.6%
Algeria Algeria 6,703,364 15.0%
Czech Republic Czech Republic 6,592,012 61.5%
Israel Israel 6,294,123 67.7%
Austria Austria 6,283,906 69.5%
Angola Angola 6,266,044 18.5%
Mozambique Mozambique 6,257,220 19.4%
Nigeria Nigeria 6,183,844 2.9%
Hungary Hungary 6,087,474 63.2%
Tunisia Tunisia 6,020,234 50.4%
Guatemala Guatemala 5,837,334 32.0%
Switzerland Switzerland 5,828,268 66.9%
Rwanda Rwanda 5,744,232 43.3%
Ethiopia Ethiopia 5,466,920 4.6%
Singapore Singapore 5,071,148 93.0%
Azerbaijan Azerbaijan 5,063,688 49.5%
Hong Kong Hong Kong 4,720,752 62.5%
Bolivia Bolivia 4,688,731 39.6%
Denmark Denmark 4,550,648 78.3%
El Salvador El Salvador 4,411,456 67.7%
Kenya Kenya 4,329,464 7.9%
Afghanistan Afghanistan 4,285,440 10.8%
Finland Finland 4,274,383 77.0%
Norway Norway 4,232,802 77.4%
Jordan Jordan 4,106,866 40.0%
Honduras Honduras 3,987,966 39.6%
New Zealand New Zealand 3,866,728 75.5%
Costa Rica Costa Rica 3,860,379 75.1%
Republic of Ireland Republic of Ireland 3,851,364 77.3%
Nicaragua Nicaragua 3,842,428 57.3%
Uganda Uganda 3,838,439 8.2%
Laos Laos 3,744,740 50.8%
Zimbabwe Zimbabwe 3,719,630 24.6%
Belarus Belarus 3,415,261 36.2%
Oman Oman 3,310,409 63.4%
Paraguay Paraguay 3,279,439 45.4%
Serbia Serbia 3,248,569 47.3%
Panama Panama 3,002,844 68.5%
Tajikistan Tajikistan 2,880,326 29.5%
Uruguay Uruguay 2,748,796 78.9%
Ivory Coast Ivory Coast 2,669,432 9.9%
Kuwait Kuwait 2,668,082 61.6%
Ghana Ghana 2,651,463 8.4%
Slovakia Slovakia 2,618,462 48.0%
Qatar Qatar 2,360,308 80.5%
Mongolia Mongolia 2,259,619 67.9%
Croatia Croatia 2,151,481 52.7%
State of Palestine Palestine 1,910,794 36.6%
Lebanon Lebanon 1,888,065 27.9%
Lithuania Lithuania 1,861,496 69.2%
Bulgaria Bulgaria 1,786,530 25.9%
Libya Libya 1,661,332 23.9%
Guinea Guinea 1,649,208 12.2%
Senegal Senegal 1,319,915 7.7%
Latvia Latvia 1,264,892 67.8%
Slovenia Slovenia 1,227,059 59.0%
Bahrain Bahrain 1,186,967 67.9%
Sudan Sudan 1,154,253 2.6%
Georgia (country) Georgia 1,144,402 28.8%
Malawi Malawi 1,100,295 5.6%
Kyrgyzstan Kyrgyzstan 1,097,284 16.6%
Albania Albania 1,065,961 37.1%
Mauritania Mauritania 1,060,233 22.2%
Togo Togo 998,792 11.8%
Moldova Moldova 948,882 23.6%
Mauritius Mauritius 916,524 72.0%
Syria Syria 890,111 4.9%
North Macedonia North Macedonia 885,888 42.5%
Tanzania Tanzania 885,579 1.4%
Botswana Botswana 883,188 36.8%
Kosovo Kosovo 851,075 47.8%
Bosnia and Herzegovina Bosnia and Herzegovina 833,233 25.5%
Estonia Estonia 825,171 62.3%
Zambia Zambia 806,611 4.3%
Cameroon Cameroon 754,013 2.8%
Armenia Armenia 738,887 24.9%
Jamaica Jamaica 656,469 22.1%
Trinidad and Tobago Trinidad and Tobago 640,787 45.7%
East Timor Timor-Leste 636,271 47.4%
Fiji Fiji 633,512 70.2%
Cyprus Cyprus 617,240 68.9%
Sierra Leone Sierra Leone 603,654 7.4%
Mali Mali 598,437 2.9%
Bhutan Bhutan 589,141 75.5%
Somalia Somalia 589,128 3.6%
Lesotho Lesotho 581,857 26.9%
Yemen Yemen 537,397 1.8%
Niger Niger 506,083 2.0%
Republic of the Congo Republic of the Congo 496,643 8.8%
Liberia Liberia 494,052 9.5%
Macau Macau 480,892 73.0%
Madagascar Madagascar 473,726 1.7%
Luxembourg Luxembourg 444,171 70.0%
Malta Malta 435,135 84.3%
Brunei Brunei 401,611 91.0%
Guyana Guyana 396,840 50.2%
Maldives Maldives 395,470 72.8%
Burkina Faso Burkina Faso 364,565 1.7%
Central African Republic Central African Republic 362,298 7.4%
Namibia Namibia 355,254 13.7%
Guinea-Bissau Guinea-Bissau 346,678 17.2%
Benin Benin 339,452 2.7%
Cape Verde Cabo Verde 303,569 54.0%
Iceland Iceland 285,289 83.1%
Northern Cyprus Northern Cyprus 279,313 73.1%
Comoros Comoros 278,152 31.3%
Montenegro Montenegro 271,675 43.3%
Eswatini Eswatini 259,022 22.1%
Suriname Suriname 256,711 43.4%
Papua New Guinea Papua New Guinea 254,708 2.8%
Equatorial Guinea Equatorial Guinea 246,519 17.0%
The Gambia Gambia 236,834 9.5%
Belize Belize 227,261 56.1%
South Sudan South Sudan 185,148 1.6%
New Caledonia New Caledonia 179,591 62.3%
Chad Chad 179,130 1.1%
Gabon Gabon 166,353 7.3%
French Polynesia French Polynesia 161,102 57.0%
Barbados Barbados 153,017 53.2%
Solomon Islands Solomon Islands 150,777 21.4%
The Bahamas Bahamas 149,231 37.6%
Democratic Republic of the Congo Democratic Republic of the Congo 137,606 0.1%
Samoa Samoa 137,258 68.6%
Haiti Haiti 118,222 1.0%
Guernsey Guernsey 104,131[g]
Curaçao Curaçao 102,590 62.2%
Vanuatu Vanuatu 89,472 28.4%
Aruba Aruba 83,565 78.0%
São Tomé and Príncipe Sao Tome and Principe 82,256 36.8%
Seychelles Seychelles 81,867 82.8%
Jersey Jersey 79,571 78.7%
Djibouti Djibouti 73,592 7.3%
Tonga Tonga 72,695 68.1%
Isle of Man Isle of Man 68,248 79.9%
Antigua and Barbuda Antigua and Barbuda 61,271 62.1%
Kiribati Kiribati 57,722 47.5%
Cayman Islands Cayman Islands 57,558 86.6%
Andorra Andorra 54,999 71.1%
Saint Lucia Saint Lucia 53,818 29.2%
Bermuda Bermuda 48,464 78.0%
Gibraltar Gibraltar 40,906 121.4%
Greenland Greenland 40,224 70.7%
Faroe Islands Faroe Islands 40,205 82.0%
Grenada Grenada 39,717 35.1%
Turkmenistan Turkmenistan 32,240 0.5%
Saint Vincent and the Grenadines Saint Vincent and the Grenadines 30,118 27.1%
Turks and Caicos Islands Turks and Caicos Islands 29,210 74.5%
Dominica Dominica 28,590 39.6%
Saint Kitts and Nevis Saint Kitts and Nevis 26,851 50.1%
Sint Maarten Sint Maarten 26,750 61.6%
Monaco Monaco 26,672 67.5%
Liechtenstein Liechtenstein 25,661 67.1%
San Marino San Marino 25,433 74.8%
Caribbean Netherlands Caribbean Netherlands 19,109 72.3%
British Virgin Islands British Virgin Islands 18,137 59.6%
Cook Islands Cook Islands 12,600 71.7%
Anguilla Anguilla 9,906 65.5%
Nauru Nauru 7,612 70.0%
Tuvalu Tuvalu 6,230 52.2%
Wallis and Futuna Wallis and Futuna 6,001 54.1%
Saint Helena, Ascension and Tristan da Cunha Saint Helena, Ascension and Tristan da Cunha 4,361 71.8%
Falkland Islands Falkland Islands 2,632 75.6%
Montserrat Montserrat 1,531 30.7%
Niue Niue 1,184 73.2%
Tokelau Tokelau 968 70.8%
Burundi Burundi 874 0.0%
Pitcairn Islands Pitcairn Islands 47 100.0%
  1. ^ The Oxford–AstraZeneca COVID-19 vaccine is codenamed AZD1222,[38] and later supplied under trade names, including Vaxzevria[39] and Covishield.[40]
  2. ^ Number of people who have received at least one dose of a COVID-19 vaccine (unless noted otherwise).
  3. ^ Percentage of population that has received at least one dose of a COVID-19 vaccine. May include vaccination of non-citizens, which can push totals beyond 100% of the local population.
  4. ^ Countries which do not report the number of people who have received at least one dose are not included in the world total.
  5. ^ Includes Freely Associated States
  6. ^ Includes Vatican City
  7. ^ This country's data are the number of vaccine doses administered, not the first dose only.

As of 25 November 2021 7.85 billion COVID-19 vaccine doses had been administered worldwide, with 53.9 per cent of the global population having received at least one dose. While 29.06 million vaccines were then being administered daily, only 5.6 per cent of people in low-income countries had received at least a first vaccine by October 2021, according to official reports from national health agencies, which is collated by Our World in Data.[194]

During a pandemic on the rapid timeline and scale of COVID-19 cases in 2020, international organizations like the World Health Organization (WHO) and Coalition for Epidemic Preparedness Innovations (CEPI), vaccine developers, governments, and industry evaluated the distribution of the eventual vaccine(s).[195] Individual countries producing a vaccine may be persuaded to favor the highest bidder for manufacturing or provide first-service to their own country.[196][197][198][199][excessive citations] Experts emphasize that licensed vaccines should be available and affordable for people at the frontline of healthcare and having the greatest need.[196][197][199]

In April 2020, it was reported that the UK agreed to work with 20 other countries and global organizations including France, Germany and Italy to find a vaccine and to share the results, and that UK citizens would not get preferential access to any new COVID‑19 vaccines developed by taxpayer-funded UK universities.[200] Several companies planned to initially manufacture a vaccine at artificially low pricing, then increase prices for profitability later if annual vaccinations are needed and as countries build stock for future needs.[199]

An April 2020 CEPI report stated: "Strong international coordination and cooperation between vaccine developers, regulators, policymakers, funders, public health bodies, and governments will be needed to ensure that promising late-stage vaccine candidates can be manufactured in sufficient quantities and equitably supplied to all affected areas, particularly low-resource regions."[201] The WHO and CEPI are developing financial resources and guidelines for global deployment of several safe, effective COVID‑19 vaccines, recognizing the need is different across countries and population segments.[195][202][203][204][excessive citations] For example, successful COVID‑19 vaccines would be allocated early to healthcare personnel and populations at greatest risk of severe illness and death from COVID‑19 infection, such as the elderly or densely-populated impoverished people.[205][206]

Access

Countries have extremely unequal access to the COVID-19 vaccine. Vaccine equity has not been achieved, or even approximated. The inequity has harmed both countries with poor access and countries with good access.[207]

Nations pledged to buy doses of the COVID‑19 vaccine before the doses were available. Though high-income nations represent only 14% of the global population, as of 15 November 2020, they had contracted to buy 51% of all pre-sold doses. Some high-income nations bought more doses than would be necessary to vaccinate their entire populations.[8]

Production of Sputnik V vaccine in Brazil, January 2021.
An elderly man receiving second dose of CoronaVac vaccine in Brazil, April 2021.

On 18 January 2021, WHO Director-General Tedros Adhanom Ghebreyesus warned of problems with equitable distribution: "More than 39 million doses of vaccine have now been administered in at least 49 higher-income countries. Just 25 doses have been given in one lowest-income country. Not 25 million; not 25 thousand; just 25."[208]

In March, it was revealed the US attempted to convince Brazil not to purchase the Sputnik V COVID-19 vaccine, fearing "Russian influence" in Latin America.[209] Some nations involved in long-standing territorial disputes have reportedly had their access to vaccines blocked by competing nations; Palestine has accused Israel of blocking vaccine delivery to Gaza, while Taiwan has suggested that China has hampered its efforts to procure vaccine doses.[210][211][212]

A single dose of the COVID‑19 vaccine by AstraZeneca would cost 47 Egyptian pounds (EGP), and the authorities are selling it between 100 and 200 EGP. A report by Carnegie Endowment for International Peace cited the poverty rate in Egypt as around 29.7 percent, which constitutes approximately 30.5 million people, and claimed that about 15 million of the Egyptians would be unable to gain access to the luxury of vaccination. A human rights lawyer, Khaled Ali, launched a lawsuit against the government, forcing them to provide vaccination free of cost to all members of the public.[213]

According to immunologist Dr. Anthony Fauci, mutant strains of the virus and limited vaccine distribution pose continuing risks and he said: "we have to get the entire world vaccinated, not just our own country."[214] Edward Bergmark and Arick Wierson are calling for a global vaccination effort and wrote that the wealthier nations' "me-first" mentality could ultimately backfire because the spread of the virus in poorer countries would lead to more variants, against which the vaccines could be less effective.[215]

On 10 March 2021, the United States, Britain, European Union nations and other WTO members blocked a push by more than eighty developing countries to waive COVID‑19 vaccine patent rights in an effort to boost production of vaccines for poor nations.[216] On 5 May 2021, the Biden administration announced that it supports waiving intellectual property protections for COVID-19 vaccines.[217] The Members of the European Parliament have backed a motion demanding the temporary lifting of intellectual properties rights for COVID‑19 vaccines.[218] Commission vice-president Valdis Dombrovskis, stressed that while the EU is ready to discuss the issue of patent waivers, its proposed solutions include limiting export restrictions, resolving production bottlenecks, looking into compulsory licensing, investing in manufacturing capacity in developing countries and increasing contributions to the COVAX scheme.[219]

COVID-19 mass vaccination queue in Finland, June 2021.
A drive-through COVID-19 vaccination center in Iran, August 2021.

In a meeting in April 2021, the World Health Organization's emergency committee addressed concerns of persistent inequity in the global vaccine distribution.[220] Although 9 percent of the world's population lives in the 29 poorest countries, these countries had received only 0.3% of all vaccines administered as of May 2021.[221] On 15 March, Brazilian journalism agency Agência Pública reported that the country vaccinated about twice as many people who declare themselves white than black and noted that mortality from COVID-19 is higher in the black population.[222]

In May 2021, UNICEF made an urgent appeal to industrialised nations to pool their excess COVID-19 vaccine capacity to make up for a 125-million-dose gap in the COVAX program. The program mostly relied on the Oxford–AstraZeneca COVID-19 vaccine produced by Serum Institute of India, which faced serious supply problems due to increased domestic vaccine needs in India from March to June 2021. Only a limited amount of vaccines can be distributed efficiently, and the shortfall of vaccines in South America and parts of Asia are due to a lack of expedient donations by richer nations. International aid organisations have pointed at Nepal, Sri Lanka, and Maldives as well as Argentina and Brazil, and some parts of the Caribbean as problem areas, where vaccines are in short supply. In mid-May 2021, UNICEF was also critical of the fact that most proposed donations of Moderna and Pfizer vaccines were not slated for delivery until the second half of 2021, or early 2022.[223]

On 1 July 2021, the heads of the World Bank Group, International Monetary Fund, World Health Organization and World Trade Organization said in a joint statement: "As many countries are struggling with new variants and a third wave of COVID-19 infections, accelerating access to vaccines becomes even more critical to ending the pandemic everywhere and achieving broad-based growth. We are deeply concerned about the limited vaccines, therapeutics, diagnostics, and support for deliveries available to developing countries."[224][225] In July 2021, The BMJ reported that countries have thrown out over 250,000 vaccine doses as supply exceeded demand and strict laws prevented the sharing of vaccines.[226] A survey by The New York Times found that over a million doses of vaccine had been thrown away in ten U.S. states because federal regulations prohibit recalling them, preventing their redistribution abroad.[227] Furthermore, doses donated close to expiration often cannot be administered quickly enough by recipient countries and end up having to be discarded.[228]

Amnesty International and Oxfam International have criticized the support of vaccine monopolies by the governments of producing countries, noting that this is dramatically increasing the dose price by five times and often much more, creating an economic barrier to access for poor countries.[229][230] Médecins Sans Frontières (Doctors without Borders) has also criticized vaccine monopolies and repeatedly called from their suspension, supporting the TRIPS Waiver. The waiver was first proposed in October 2020, and has support from most countries, but delayed by opposition EU (especially Germany), UK, Norway, and Switzerland, among others. MSF called for a Day of Action in September 2021 to put pressure on the WTO Minister's meeting in November, which is expected to discuss the TRIPS IP waiver.[231][232][233]

Inside of a vaccination center in Brussels, Belgium, February 2021.

On 4 August 2021, to reduce unequal distribution between rich and poor countries, the WHO called for a moratorium on a booster dose at least until the end of September. However, on 18 August, the United States government announced plans to offer booster doses 8 months after the initial course to the general population, starting with priority groups. Before the announcement, the WHO harshly criticized this type of decision, citing the lack of evidence for the need for boosters, except for patients with specific conditions. At this time, vaccine coverage of at least one dose was 58% in high-income countries and only 1.3% in low-income countries, and 1.14 million Americans already received an unauthorized booster dose. US officials argued that waning efficacy against mild and moderate disease might indicate reduced protection against severe disease in the coming months. Israel, France, Germany, and the United Kingdom have also started planning boosters for specific groups.[234][235][236] On 14 September 2021, more than 140 former world leaders, and Nobel laureates, including former President of France François Hollande, former Prime Minister of the United Kingdom Gordon Brown, former Prime Minister of New Zealand Helen Clark, and Professor Joseph Stiglitz, called on the candidates to be the next German chancellor to declare themselves in favour of waiving intellectual property rules for COVID-19 vaccines and transferring vaccine technologies.[237]

During his first international trip, President of Peru Pedro Castillo spoke at the seventy-sixth session of the United Nations General Assembly on 21 September 2021, proposing the creation of an international treaty signed by world leaders and pharmaceutical companies to guarantee universal vaccine access, arguing "The battle against the pandemic has shown us the failure of the international community to cooperate under the principle of solidarity".[238][239]

Optimizing the societal benefit of vaccination may benefit from a strategy that is tailored to the state of the pandemic, the demographics of a country, the age of the recipients, the availability of vaccines, and the individual risk for severe disease: In the UK, the interval between prime and boost dose was extended to vaccinate as many persons as early as possible,[240] many countries are starting to give an additional booster shot to the immunosuppressed[241][242] and the elderly,[243] and research predicts an additional benefit of personalizing vaccine dose in the setting of limited vaccine availability when a wave of virus Variants of Concern hits a country.[244]

While vaccines substantially reduce the probability of infection, it is still possible for fully vaccinated people to contract and spread COVID-19.[245] Public health agencies have recommended that vaccinated people continue using preventive measures (wear face masks, social distance, wash hands) to avoid infecting others, especially vulnerable people, particularly in areas with high community spread. Governments have indicated that such recommendations will be reduced as vaccination rates increase and community spread declines.[246]

In September 2021, it was estimated that the world would have manufactured enough vacine to vaccinate everyone on the planet by January 2022. Vaccine hoarding, booster shots, a lack of funding for vaccination infrastructure, and other forms of inequality mean that it is expected that many countries will still have inadequate vaccination.[247]

Economics

Moreover, an unequal distribution of vaccines will deepen inequality and exaggerate the gap between rich and poor and will reverse decades of hard-won progress on human development.
— United Nations, COVID vaccines: Widening inequality and millions vulnerable[248]

Vaccine inequity damages the global economy, disrupting the global supply chain.[207] Most vaccines were being reserved for wealthy countries, as of September 2021,[248] some of which have more vaccine than is needed to fully vaccinate their populations.[8] When people, undervaccinated, needlessly die, suffer disability, and live under lockdown restrictions, they cannot supply the same goods and services. This harms the economies of undervaccinated and overvaccinated countries alike. Since rich countries have larger economies, rich countries may lose more money to vaccine inequity than poor ones,[207] though the poor ones will lose a higher percentage of GDP and suffer longer-term effects.[249] High-income countries would profit an estimated US $4.80 for every $1 spent on giving vaccines to lower-income countries.[207]

The International Monetary Fund sees the vaccine divide between rich and poor nations as a serious obstacle to a global economic recovery.[250] Vaccine inequity disproportionately affects refuge-providing states, as they tend to be poorer, and refugees and displaced people are economically more vulnerable even within those low-income states, so they have suffered more economically from vaccine inequity.[251]

Liability

Several governments agreed to shield pharmaceutical companies like Pfizer and Moderna from negligence claims related to COVID-19 vaccines (and treatments), as in previous pandemics, when governments also took on liability for such claims.

In the US, these liability shields took effect on 4 February 2020, when the US Secretary of Health and Human Services Alex Azar published a notice of declaration under the Public Readiness and Emergency Preparedness Act (PREP Act) for medical countermeasures against COVID‑19, covering "any vaccine, used to treat, diagnose, cure, prevent, or mitigate COVID‑19, or the transmission of SARS-CoV-2 or a virus mutating therefrom". The declaration precludes "liability claims alleging negligence by a manufacturer in creating a vaccine, or negligence by a health care provider in prescribing the wrong dose, absent willful misconduct." In other words, absent "willful misconduct", these companies can not be sued for money damages for any injuries that occur between 2020 and 2024 from the administration of vaccines and treatments related to COVID-19.[252] The declaration is effective in the United States through 1 October 2024.[252]

In December 2020, the UK government granted Pfizer legal indemnity for its COVID-19 vaccine.[253]

In the European Union, the COVID‑19 vaccines are licensed under a Conditional Marketing Authorisation which does not exempt manufacturers from civil and administrative liability claims.[254] While the purchasing contracts with vaccine manufacturers remain secret, they do not contain liability exemptions even for side-effects not known at the time of licensure.[255]

The Bureau of Investigative Journalism, a nonprofit news organization, reported in an investigation that unnamed officials in some countries, such as Argentina and Brazil, said that Pfizer demanded guarantees against costs of legal cases due to adverse effects in the form of liability waivers and sovereign assets such as federal bank reserves, embassy buildings or military bases, going beyond the expected from other countries such as the US.[256] During the pandemic parliamentary inquiry in Brazil, Pfizer's representative said that its terms for Brazil are the same as for all other countries with which it has signed deals.[257]

Misinformation and hesitancy

A protest against COVID-19 vaccination in London, United Kingdom
Anti-vaccination activists and other people in multiple countries have spread a variety of unfounded conspiracy theories about COVID-19 vaccines based on misunderstood science, religion, and other factors. Theories including overblown claims about side effects, a story about COVID-19 being spread by 5G, misrepresentations about how the immune system works, and when and how COVID-19 vaccines are made have proliferated among masses making them averse to vaccination.[258] This has led to governments and private organisations around the world introducing measures to encourage vaccination such as lotteries,[259] mandates[260] and free entry to events,[261] which has in turn led to further misinformation about the legality and effect of these measures themselves.[262]

See also

Notes

  1. ^ The table data is automatically updated daily by a bot; see Template:COVID-19 data for more information. Scroll down past the table to find the documentation and the main reference. See also: Category:Automatically updated COVID-19 pandemic table templates.

References

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Further reading

Vaccine protocols

External links