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Corpuscle (//) may refer to:
- a small free floating biological cell, especially a blood cell
- a nerve ending such as Meissner's corpuscle or a Pacinian corpuscle
- any member of Corpus Christi College, Cambridge or Corpus Christi College, Oxford
- a subatomic particle made obsolete by the modern electron and used in J.J. Thomson's plum pudding model of the atom
- a single, infinitesimally small particle of light. Isaac Newton proposed this term to represent a concept of light—as opposed to a photon, which exhibits wave and particle characteristics.
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