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Corticotropes (or corticotrophs) are basophilic cells in the anterior pituitary that produce melanocyte-stimulating hormone, adrenocorticotropic hormone (ACTH) and lipotropin. The cells produce pro-opiomelanocortin (POMC) which undergoes cleavage to ACTH and β-lipotropin (β-LPH). These cells respond to corticotropin releasing hormone (CRH) and make up about 20% of the cells in the anterior pituitary.
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