|Function||Production of melanocyte-stimulating hormone, adrenocorticotropic hormone (ACTH) and lipotropin|
|Anatomical terms of microanatomy
Corticotropes (or corticotrophs) are basophilic cells in the anterior pituitary that produce melanocyte-stimulating hormone, adrenocorticotropic hormone (ACTH) and lipotropin. The cells produce pro-opiomelanocortin (POMC) which undergoes cleavage to ACTH and β-lipotropin (β-LPH). These cells respond to corticotropin releasing hormone (CRH) and make up about 20% of the cells in the anterior pituitary.
Coticotrophs are cells part of the anterior pituitary gland. They release adrenocorticotropic hormone, which is also referred to as corticotropin. the release of this hormone is controlled by corticotropn releasing hormone which is formed in the cell bodies of neurosecretory cells of the hypothalamus, and passes to the anterior pituitary via the hypophyseal portal system. The adrenocorticotropin hormone stimulates the adrenal cortex to release glucocorticoids and some MSH- (melanocyte stimulating hormone). Stimuli for the release of corticotropin releasing hormones are Low blood pressure Interleukin 1 glucocorticoids inhibit the release of corticotropin releasing hormone and Adrenocorticotropin hormone By Musa
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