Universidad Católica San Antonio de Murcia Club de Fútbol was founded in 1999 and had previously a team which played in Tercera División from 2000 to 2005. In parallel was founded in 2004 the Club de Fútbol Los Garres, making its first appearance in Tercera División in 2008–09 as Murcia Deportivo Club de Fútbol. In 2009 a businessman from Beniaján, Murcia, acquired the club and moved it to his local town; one year later the club relocated again, now to Sangonera la Verde, and, in 2011, UCAM became its new owner.
At the end of the 2011–12 season, after Orihuela suffered relegation from Segunda División B due to irregularities, UCAM Murcia took its place. After suffering relegation, the club bounced back to the third level immediately, and achieved a respectable second place in his group during the 2014–15 campaign; it missed out promotion in the play-offs, after being knocked out by Bilbao Athletic B, which would later achieve promotion.
The first season of UCAM in the second flight would be short-lived, as they ended in the 19th position, and subsequently relegated to the third tier, after being defeated in a do-or-die game by Gimnàstic de Tarragona in the last matchday.
Universidad Católica de Murcia Club de Fútbol’s highest home attendance is 5,877, in a 2016–17 Segunda División match against Rayo Vallecano. The club’s two main supporters groups are Los T-UCAM who were founded in 2015 and Los Blue Gold who were founded in 2016.