It was originally scheduled for an early 2006 release but the release date was put back.
"Hush Boy", "Take Me Back to Your House", were released as singles. "Hey U" was released as a single to digital download services in March 2007.
Compared with traditional songwriting, the band approach to creating music might appear to work backward. For example, on "Hush Boy", they created the song's melody with vocalist Vula Malinga over a basic track. Once it was recorded, they kept only Vula's vocal and rebuilt all the music under her voice from scratch. The band says this approach allows for a tremendous amount of freedom to explore different sounds.
The album was given a score of 73 out of 100 by Metacritic based on "generally favorable reviews", although less-so than Basement Jaxx's previous records.Allmusic gave it 4 out of 5 stars, writing "at this point, it's impossible to imagine them topping themselves; an album that is merely deeply engaging and wildly entertaining cannot be considered a flop in any way." In his Consumer Guide, Robert Christgau gave the album a two-star honorable mention (), stating, "Interchangeable ladies detail interchangeable ups and downs over beats whose changeabilty supposedly renders them indelible," and picked out two songs from the album, "Take Me Back to Your House" and "Run 4 Cover".
Pitchfork Media, while still giving the album a positive review, wrote, "Crazy Itch Radio isn't a bad album by any means; it just doesn't scream "best album of the year" from the moment you put it on."NME, on the other hand, was more critical, writing "It's easy enough to ignore until a real stinker passes by."