Cuevavirus

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Cuevavirus
Virus classification
Group: Group V ((-)ssRNA)
Order: Mononegavirales
Family: Filoviridae
Genus: Cuevavirus
Type species
Lloviu cuevavirus

Cuevavirus is a genus in the family Filoviridae, which is included in the order Mononegavirales. Cuevavirus includes a single species, Lloviu cuevavirus, with one member, Lloviu virus (LLOV).[1][2] LLOV is a distant relative of the more widely known Ebola and Marburg viruses. Members of the genus are referred to as cuevaviruses. Cueva is derived from the Spanish word for cave.

Genus inclusion criteria[edit]

A virus that fulfills the criteria for being a member of the family Filoviridae is a member of the genus Cuevavirus if:[1]

  • it is endemic in France, Portugal, or Spain
  • its fourth gene (GP) encodes four proteins (sGP, ssGP, Δ-peptide, and GP1,2) using cotranscriptional editing to express ssGP and GP1,2 and proteolytic cleavage to express sGP and Δ-peptide
  • its genome differs from that of Marburg virus (variant Musoke) by ≥50% and from that of Lloviu virus (variant Bat86) by <50% at the nucleotide level

References[edit]

  1. ^ a b Kuhn, J. H.; Becker, S.; Ebihara, H.; Geisbert, T. W.; Johnson, K. M.; Kawaoka, Y.; Lipkin, W. I.; Negredo, A. I.; Netesov, S. V.; Nichol, S. T.; Palacios, G.; Peters, C. J.; Tenorio, A.; Volchkov, V. E.; Jahrling, P. B. (2010). "Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–2103. doi:10.1007/s00705-010-0814-x. PMC 3074192Freely accessible. PMID 21046175. 
  2. ^ Negredo, A.; Palacios, G.; Vázquez-Morón, S.; González, F. L.; Dopazo, H. N.; Molero, F.; Juste, J.; Quetglas, J.; Savji, N.; de la Cruz Martínez M; Herrera, J. E.; Pizarro, M.; Hutchison, S. K.; Echevarría, J. E.; Lipkin, W. I.; Tenorio, A. (2011). Basler, Christopher F, ed. "Discovery of an Ebolavirus-Like Filovirus in Europe". PLoS Pathogens. 7 (10): e1002304. doi:10.1371/journal.ppat.1002304. PMC 3197594Freely accessible. PMID 22039362. 

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