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Cuyahoga may refer to:
- Cuyahoga County, Ohio
- Cuyahoga Falls, Ohio
- Cuyahoga Heights, Ohio
- Cuyahoga River, northeast Ohio
- Cuyahoga Valley National Park, Ohio
- USCGC Cuyahoga (WIX-157), a U.S. Coast Guard Cutter that sank in the Chesapeake Bay in 1978 after a collision
- USS Cuyahoga (AG-26), built in 1927 and transferred from the United States Coast Guard to the Navy in 1933
- Cuyahoga (ship, 1943), a Maritimer, built to the design of the United States Maritime Commission, see Lower Lakes Towing
- "Cuyahoga" (song), a song by R.E.M. on their 1986 album Lifes Rich Pageant
| disambiguation page lists articles associated with the title Cuyahoga.
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