Cyanoacetamide

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2-Cyanoacetamide
Cyanoacetamide.svg
Names
IUPAC name
2-Cyanoacetamide
Other names
Malonamide nitrile
3-Nitrilopropionamide
Identifiers
3D model (JSmol)
ChemSpider
EC Number 203-531-8
UNII
Properties
C3H4N2O
Molar mass 84.08 g·mol−1
Density 1.163 g/cm3
Melting point 119 to 121 °C (246 to 250 °F; 392 to 394 K)
Boiling point 351.2 °C (664.2 °F; 624.3 K)
Hazards
R-phrases (outdated) R8 R23/24/25 R36/38 R45
S-phrases (outdated) S17 S45
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

2-Cyanoacetamide is a organic compound. It is an acetic amide with a nitrile functional group.

Uses[edit]

Cyanoacetamide is used in spectrofluorimetric methods to determine the activity of antihistamine H1 receptor antagonistic drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride.[1]

Preparation[edit]

2-Cyanoacetamide is prepared from chloroacetic acid via Kolbe nitrile synthesis[2] followed by Fischer esterification and ester aminolysis.[3]

See also[edit]

References[edit]

  1. ^ Ibrahim, F.; Sharaf El-Din, M. K.; Eid, M.; Wahba, M. E. K. (2011). "Spectrofluorimetric Determination Of Some H1 Receptor Antagonist Drugs In Pharmaceutical Formulations And Biological Fluids". International Journal of Pharmaceutical Sciences and Research. 21 (8): 2056–2072. doi:10.13040/IJPSR.0975-8232.2(8).2056-72. 
  2. ^ Inglis, J. K. H. (1928). "Ethyl Cyanoacetate". Organic Syntheses. 8: 74. doi:10.15227/orgsyn.008.0074. 
  3. ^ Corson, B. B.; Scott, R. W.; Vose, C. E. (1941). "Cyanoacetamide". Organic Syntheses. 1: 179. doi:10.15227/orgsyn.009.0036.