Cyanodothiepin

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Cyanodothiepin
Cyanodothiepin.svg
Clinical data
ATC code
  • None
Identifiers
CAS Number
ChemSpider
Chemical and physical data
Formula C20H20N2S
Molar mass 320.45 g/mol
3D model (Jmol)

Cyanodothiepin (developmental code name BTS-56,424) is a tricyclic antidepressant (TCA) acting as a potent and highly selective (over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin that was never marketed.[1][2][3] It also has moderate affinity for the mACh receptors and weak/negligible affinity for the α1-adrenergic, 5-HT2A, D1, and D2 receptors;[1][2][3] the H1 receptor has not been assayed,[3] but cyanodothiepin is less sedating than the related drug cianopramine, suggesting its antihistamine activity is not as pronounced as other TCAs.[1][3] Cyanodothiepin is active in the forced swimming test (FST), inferring that it may possess antidepressant properties in humans. However, it is only weakly active compared to cianopramine and imipramine in monoamine depletion-based tests of antidepressant potential.[1]

See also[edit]

References[edit]

  1. ^ a b c d Luscombe, G. P.; Buckett, W. R. (1993). "Pharmacology of Cyanodothiepin (BTS 56 424), a Selective 5-Hydroxytryptamine Reuptake Inhibitor". Drug Development Research. 29 (3): 235–248. doi:10.1002/ddr.430290311. 
  2. ^ a b Jucker , E. (2000). Progress in Drug Research. Birkhäuser. pp. 79–80. ISBN 978-3-7643-6113-6. Retrieved 2011-11-25. 
  3. ^ a b c d Olivier, B.; van Wijngaarden, I.; Soudijn, W. (1997). Serotonin Receptors and their Ligands. Elsevier. p. 332. ISBN 978-0-444-82041-9. Retrieved 2011-11-25.