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- Adenylyl cyclase, which forms cyclic AMP from adenosine triphosphate (EC 126.96.36.199)
- Guanylyl cyclase, which forms cyclic GMP from guanosine triphosphate (EC 188.8.131.52)
- Protein cyclase, a ligase enzyme that produces backbone-cyclised proteins by intramolecular transpeptidation
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