Cyclic nucleotide-gated channel alpha 3

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Cyclic nucleotide gated channel alpha 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CNGA3 ; ACHM2; CCNC1; CCNCa; CCNCalpha; CNCG3; CNG3
External IDs OMIM600053 MGI1341818 HomoloGene994 IUPHAR: 396 ChEMBL: 1628463 GeneCards: CNGA3 Gene
RNA expression pattern
PBB GE CNGA3 207261 at tn.png
More reference expression data
Species Human Mouse
Entrez 1261 12790
Ensembl ENSG00000144191 ENSMUSG00000026114
UniProt Q16281 Q9JJZ8
RefSeq (mRNA) NM_001079878 NM_001282010
RefSeq (protein) NP_001073347 NP_001268939
Location (UCSC) Chr 2:
98.35 – 98.4 Mb
Chr 1:
37.21 – 37.26 Mb
PubMed search [1] [2]

Cyclic nucleotide-gated cation channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene.[1][2][3][4]


This gene encodes a member of the cyclic nucleotide-gated cation channel protein family, which is required for normal vision and olfactory signal transduction. Two alternatively-spliced transcripts encoding different isoforms have been described.[4]

Clinical relevance[edit]

Variants in this gene have been shown to cause achromatopsia[5] and colour blindness.

See also[edit]


  1. ^ Distler M, Biel M, Flockerzi V, Hofmann F (Mar 1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. 
  2. ^ Wissinger B, Muller F, Weyand I, Schuffenhauer S, Thanos S, Kaupp UB, Zrenner E (Apr 1998). "Cloning, chromosomal localization and functional expression of the gene encoding the alpha-subunit of the cGMP-gated channel in human cone photoreceptors". Eur J Neurosci 9 (12): 2512–21. doi:10.1111/j.1460-9568.1997.tb01680.x. PMID 9517456. 
  3. ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. 
  4. ^ a b "Entrez Gene: CNGA3 cyclic nucleotide gated channel alpha 3". 
  5. ^ Lam K, Guo H, Wilson GA, Kohl S, Wong F (2011). "Identification of variants in CNGA3 as cause for achromatopsia by exome sequencing of a single patient". Arch. Ophthalmol. 129 (9): 1212–7. doi:10.1001/archophthalmol.2011.254. PMID 21911670. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.