Cyclic vomiting syndrome

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Cyclic vomiting syndrome
Other namesCVS

Cyclic vomiting syndrome (US English) or cyclical vomiting syndrome (UK English) is a chronic functional condition of unknown cause characterised by recurring attacks of intense nausea, vomiting, and sometimes abdominal pain, headaches, or migraines. CVS typically develops during childhood, usually between ages 3 and 7; although it often remits during adolescence, it can persist into adult life.[1][2][3]

Signs and symptoms[edit]

Sufferers may vomit or retch 6–12 times in an hour and an episode may last from a few hours to over three weeks and in some cases months, with a median episode duration of 41 hours.[4] Acid, bile and, if the vomiting is severe, blood may be vomited. Some sufferers will ingest water to reduce the irritation of bile and acid on the esophagus during emesis. Between episodes, the sufferer is usually normal and healthy otherwise but can be in a weak state of fatigue or experience muscle pain. In approximately half of cases the attacks, or episodes, occur in a time-related manner. Each attack is stereotypical; that is, in any given individual, the timing, frequency and severity of attacks is similar.

Episodes may happen every few days, every few weeks or every few months. For some sufferers, there is not a pattern in time that can be recognized. Some sufferers have a warning of an attack; they may experience a prodrome, usually intense nausea and pallor, heightened sensitivity, especially to light, though sensitivity to smell, sound, pressure, and temperature, as well as oncoming muscle pain and fatigue, are also reported by some patients. The majority of sufferers can identify triggers that may precipitate an attack. The most common are various foods, infections (e.g., colds), menstruation, extreme physical exertion, lack of sleep, and psychological stresses, both positive and negative.

A sufferer may also be light-sensitive (photophobic), sound-sensitive (phonophobic) or, less frequently, temperature- or pressure-sensitive during an attack.[1] Some sufferers also have a strong urge to bathe in warm or cold water. Some sufferers report that they experience a restless sensation or stinging pain along the spine, hands, and feet followed by weakness in both legs. Some of these symptoms may be due to dehydration rather than the underlying cause of CVS.


Many affected individuals have a family history of related conditions, such as migraines, in their mothers and maternal relatives, suggesting mitochondrial inheritance. Single base-pair and DNA rearrangements in the mitochondrial DNA have been associated with these traits.[5]


The cause of CVS has not been determined and there are no diagnostic tests for CVS. Several other medical conditions, such as cannabinoid hyperemesis syndrome, can mimic the same symptoms, and it is important to rule these out. If all other possible causes have been excluded, a diagnosis of CVS may be appropriate.

Once formal investigations to rule out gastrointestinal or other causes have been conducted, these tests do not need to be repeated in the event of future episodes.[1]

Diagnostic criteria[edit]

Although there are differences[example needed] between early-onset CVS (babies and children) and late-onset CVS (in adults),[6] there are established criteria to aid in diagnosis of CVS, namely:

  1. A history of three or more periods of intense, acute nausea and unremitting vomiting, as well as pain in some cases, lasting hours to days and even weeks or months[7]
  2. Intervening symptom-free or reduced-symptom intervals, lasting weeks to months
  3. There are repeated cycles of periods (of varying duration) with intense/acute nausea, with or without vomiting, with or without severe pain, followed by periods of reduced symptoms, followed by gradual increase in CVS symptoms until it peaks (peak intensity is generally relative to cycle intensity).
  4. Exclusion of metabolic, gastrointestinal, genitourinary or central nervous system structural or biochemical disease, e.g., individuals with specific physical causes (such as intestinal malrotation)


There is no known cure for CVS, but there are medications that can be used for treatment, intervention, and prevention. There is a growing body of publications on both individual cases and the experiences of the CVS cohort. Treatment is usually on an individual basis, based on trial and error.

The most common therapeutic strategies for those already in an attack are maintenance of salt balance by appropriate intravenous fluids[8] and, in some cases, sedation. Having vomited for a long period prior to attending a hospital, patients are typically severely dehydrated. For a number of patients, potent anti-emetic drugs such as ondansetron (Zofran) or granisetron (Kytril), and dronabinol (Marinol) may be helpful in either preventing an attack, aborting an attack, or reducing the severity of an attack. Lifestyle changes may be recommended, such as extended rest and reduction of stress.[9] Because the symptoms of CVS are similar (or perhaps identical) to those of the disease well-identified as "abdominal migraine", treatment of CVS with a regimen of anti-migraine drugs, such as topiramate and amitriptyline, is showing promise in preventing recurrent attacks.

Some patients experience relief from inhaled isopropyl alcohol.[10]


Fitzpatrick et al. (2007) identified 41 children with CVS. The mean age of the sample was 6 years at the onset of the syndrome, 8 years at first diagnosis, and 13 years at follow-up. As many as 39% of the children had resolution of symptoms immediately or within weeks of the diagnosis. Vomiting had resolved at the time of follow-up in 61% of the sample. Many children, including those in the remitted group, continued to have somatic symptoms such as headaches (in 42%) and abdominal pain (in 37%).[11]

Most children who have this disorder miss on average 24 school days a year.[2] The frequency of episodes is higher for some people during times of excitement.[2] Charitable organizations to support sufferers and their families and to promote knowledge of CVS exist in several countries.


There is little hard evidence of death as a result of the condition. However, in severe cases the fluid loss can lead to potentially life-threatening electrolyte imbalances. The patient can also become malnourished if the attacks last too long without adequate replenishment of nutrients. With adequate medical interventions, most patients can be properly supported during an episode.[9]


The average age at onset is 3–7 years, but CVS has been seen in infants who are as young as 6 days and in adults who are as old as 73 years.[12] Typical delay in diagnosis from onset of symptoms is 2.7–3 years.[12] Females show a slight predominance over males; the female-to-male ratio is 57:43.[12]

It is not clear how common the condition is.[clarify] A prospective study found that 3 in 100,000 five-year-olds are diagnosed with the condition.[13] Two published studies[14][15] on childhood CVS suggest nearly 2% of school-age children may have CVS. However, diagnosis is problematic and, as knowledge of CVS has increased in recent years, more and more cases are emerging.[citation needed]


Cyclic vomiting syndrome was first described in France by Swiss physician Henri Clermond Lombard[16] and first described in the English language by pediatrician Samuel Gee in 1882.[17]

It has been suggested that Charles Darwin's adult illnesses may have been due to this syndrome.[18][further explanation needed]

See also[edit]


  1. ^ a b c Lindley, Keith J; Andrews, Paul L (2005). "Pathogenesis and Treatment of Cyclical Vomiting". Journal of Pediatric Gastroenterology & Nutrition. 41 (Suppl 1): S38–40. doi:10.1097/01.scs.0000180299.04731.cb. PMID 16131963.
  2. ^ a b c Li, B UK; Lefevre, Frank; Chelimsky, Gisela G; Boles, Richard G; Nelson, Susanne P; Lewis, Donald W; Linder, Steven L; Issenman, Robert M; et al. (2008). "North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Statement on the Diagnosis and Management of Cyclic Vomiting Syndrome". Journal of Pediatric Gastroenterology and Nutrition. 47 (3): 379–93. doi:10.1097/MPG.0b013e318173ed39. PMID 18728540.
  3. ^ Abell, T. L.; Adams, K. A.; Boles, R. G.; Bousvaros, A.; Chong, S. K. F.; Fleisher, D. R.; Hasler, W. L.; Hyman, P. E.; et al. (2008). "Cyclic vomiting syndrome in adults" (PDF). Neurogastroenterology & Motility. 20 (4): 269–84. doi:10.1111/j.1365-2982.2008.01113.x. PMID 18371009.
  4. ^ Li, BU; Fleisher, DR (1999). "Cyclic vomiting syndrome: Features to be explained by a pathophysiologic model". Digestive Diseases and Sciences. 44 (8 Suppl): 13S–18S. doi:10.1023/A:1026662402734. PMID 10490033.
  5. ^ "What is cyclic vomiting syndrome?".
  6. ^ Boles, R. G.; Zaki, E. A.; Lavenbarg, T.; Hejazi, R.; Foran, P.; Freeborn, J.; Trilokekar, S.; McCallum, R. (September 2009). "Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A". Neurogastroenterology & Motility. 21 (9): 936–e72. doi:10.1111/j.1365-2982.2009.01305.x. ISSN 1365-2982. PMID 19368653.
  7. ^ Sagar, Sood, Gracie, Gold, To, Law, Ford (2018). "Cyclic vomiting syndrome is a prevalent and under-recognized condition in the gastroenterology outpatient clinic". Neurogastroenterology & Motility. 30 – via EBSCOhost.CS1 maint: multiple names: authors list (link)
  8. ^ Hejazi, McCallum (2014). "Cyclic vomiting syndrome: treatment options". Experimental Brain Research. 8: 2549–2552 – via EBSCOhost.
  9. ^ a b "Cyclical vomiting syndrome". NHS Gov.UK. 2017-10-18.
  10. ^ "Inhaled Isopropyl Alcohol Superior to Oral Ondansetron as an Antiemetic". New England Journal of Medicine Journal Watch 2018-03-09.
  11. ^ Fitzpatrick, E; Bourke B; Drumm B; Rowland M (April 2008). "The incidence of cyclic vomiting syndrome in children: population-based study". Am J Gastroenterol. 103 (4): 991–5. doi:10.1111/j.1572-0241.2007.01668.x. PMID 18070235.
  12. ^ a b c Li, B U.K; Misiewicz, Larry (2003). "Cyclic vomiting syndrome: A brain–gut disorder". Gastroenterology Clinics of North America. 32 (3): 997–1019. doi:10.1016/S0889-8553(03)00045-1. PMID 14562585.
  13. ^ Drumm, BR; Bourke; Drummond, J; et al. (2012). "Cyclical vomiting syndrome in children: a prospective study". Neurogastroenterology & Motility. 24 (10): 922–927. doi:10.1111/j.1365-2982.2012.01960.x. PMID 22762244.
  14. ^ Abu-Arafeh, I; Russell, G (1995). "Cyclical vomiting syndrome in children: a population-based study". J Pediatr Gastroenterol Nutr. 21 (4): 454–458. doi:10.1097/00005176-199511000-00014. PMID 8583299.
  15. ^ Cullen, K; Macdonald, WB (1963). "The periodic syndrome. Its nature and prevalence". Med J Australia. 50 (2): 67–72.
  16. ^ Lombard HC. Description d'une névrose de la digestion, caractérisée par des crises périodiques de vomissements et une profonde modification de l'assimilation. Gazette Medicale de Paris. 1861:312.
  17. ^ Gee S. On fitful or recurrent vomiting. St Bartholomew Hospital Reports. 1882;18:1.
  18. ^ Hayman, J. A (2009). "Darwin's illness revisited". BMJ. 339: b4968. doi:10.1136/bmj.b4968. PMID 20008377.

Further reading[edit]

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