Cyclin-dependent kinase 10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cyclin-dependent kinase 10
Identifiers
Symbols CDK10 ; PISSLRE
External IDs OMIM603464 MGI2448549 HomoloGene55769 ChEMBL: 1795191 GeneCards: CDK10 Gene
EC number 2.7.11.22
RNA expression pattern
PBB GE CDK10 203469 s at tn.png
PBB GE CDK10 203468 at tn.png
PBB GE CDK10 210622 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8558 234854
Ensembl ENSG00000185324 ENSMUSG00000033862
UniProt Q15131 Q3UMM4
RefSeq (mRNA) NM_001098533 NM_194444
RefSeq (protein) NP_001092003 NP_919426
Location (UCSC) Chr 16:
89.68 – 89.7 Mb
Chr 8:
123.22 – 123.23 Mb
PubMed search [1] [2]

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[1][2][3]

Function[edit]

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[3]

Interactions[edit]

Cyclin-dependent kinase 10 has been shown to interact with ETS2.[4]

References[edit]

  1. ^ Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene 9 (7): 2097–103. PMID 8208557. 
  2. ^ Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene 9 (10): 3037–41. PMID 8084611. 
  3. ^ a b "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". 
  4. ^ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. 

Further reading[edit]

  • Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995). "The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle". Cancer Res. 55 (18): 3992–5. PMID 7664269. 
  • Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K, Croce CM (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308. 
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C, d'apolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A (1999). "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer". Genomics 56 (1): 90–7. doi:10.1006/geno.1998.5676. PMID 10036189. 
  • Sergère JC, Thuret JY, Le Roux G, Carosella ED, Leteurtre F (2000). "Human CDK10 gene isoforms". Biochem. Biophys. Res. Commun. 276 (1): 271–7. doi:10.1006/bbrc.2000.3395. PMID 11006117. 
  • Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Kasten M, Giordano A (2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. 
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. 
  • Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 

External links[edit]