Cyclin-dependent kinase 10

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Cyclin-dependent kinase 10
Symbols CDK10 ; PISSLRE
External IDs OMIM603464 MGI2448549 HomoloGene55769 IUPHAR: 1962 ChEMBL: 1795191 GeneCards: CDK10 Gene
EC number
RNA expression pattern
PBB GE CDK10 203469 s at tn.png
PBB GE CDK10 203468 at tn.png
PBB GE CDK10 210622 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8558 234854
Ensembl ENSG00000185324 ENSMUSG00000033862
UniProt Q15131 Q3UMM4
RefSeq (mRNA) NM_001098533 NM_194444
RefSeq (protein) NP_001092003 NP_919426
Location (UCSC) Chr 16:
89.75 – 89.76 Mb
Chr 8:
123.22 – 123.23 Mb
PubMed search [1] [2]

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[1][2][3]


The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[3]


Cyclin-dependent kinase 10 has been shown to interact with ETS2.[4]


  1. ^ Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene 9 (7): 2097–103. PMID 8208557. 
  2. ^ Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene 9 (10): 3037–41. PMID 8084611. 
  3. ^ a b "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". 
  4. ^ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. 

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