Cyclin-dependent kinase 4

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Cyclin-dependent kinase 4
Protein CDK4 PDB 1LD2.png
Rendering based on PDB 1LD2​.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CDK4 ; CMM3; PSK-J3
External IDs OMIM123829 MGI88357 HomoloGene55429 ChEMBL: 331 GeneCards: CDK4 Gene
EC number
RNA expression pattern
PBB GE CDK4 202246 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1019 12567
Ensembl ENSG00000135446 ENSMUSG00000006728
UniProt P11802 P30285
RefSeq (mRNA) NM_000075 NM_009870
RefSeq (protein) NP_000066 NP_034000
Location (UCSC) Chr 12:
57.75 – 57.76 Mb
Chr 10:
127.06 – 127.07 Mb
PubMed search [1] [2]

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family.


The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16INK4a. This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).[1]

Clinical significance[edit]

Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.[1]

It is regulated by Cyclin D.


Palbociclib is US FDA approved for estrogen receptor-positive advanced breast cancer.[2]


Cyclin-dependent kinase 4 has been shown to interact with:

Overview of signal transduction pathways involved in apoptosis.


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Further reading[edit]

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