Cyclin-dependent kinase 7

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CDK7
Protein CDK7 PDB 1ua2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
External IDs MGI: 102956 HomoloGene: 1363 GeneCards: CDK7
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDK7
Genomic location for CDK7
Band 5q13.2 Start 69,234,795 bp[1]
End 69,277,430 bp[1]
RNA expression pattern
PBB GE CDK7 211297 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009874

RefSeq (protein)

NP_034004

Location (UCSC) Chr 5: 69.23 – 69.28 Mb Chr 5: 100.7 – 100.73 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.[5]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.[6]

Interactions[edit]

Cyclin-dependent kinase 7 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ a b c ENSG00000277273 GRCh38: Ensembl release 89: ENSG00000134058, ENSG00000277273 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069089 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Fisher RP, Morgan DO (Aug 1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell. 78 (4): 713–24. PMID 8069918. doi:10.1016/0092-8674(94)90535-5. 
  6. ^ "Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)". 
  7. ^ Lee DK, Duan HO, Chang C (Mar 2000). "From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator". The Journal of Biological Chemistry. 275 (13): 9308–13. PMID 10734072. doi:10.1074/jbc.275.13.9308. 
  8. ^ a b c d Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Research. 55 (24): 6058–62. PMID 8521393. 
  9. ^ Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature. 371 (6494): 254–7. PMID 8078587. doi:10.1038/371254a0. 
  10. ^ a b Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Molecular and Cellular Biology. 20 (18): 6958–69. PMC 88771Freely accessible. PMID 10958691. doi:10.1128/mcb.20.18.6958-6969.2000. 
  11. ^ a b Rossignol M, Kolb-Cheynel I, Egly JM (Apr 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". The EMBO Journal. 16 (7): 1628–37. PMC 1169767Freely accessible. PMID 9130708. doi:10.1093/emboj/16.7.1628. 
  12. ^ Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (Mar 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. PMID 7533895. doi:10.1038/374283a0. 
  13. ^ Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (Mar 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". The Journal of Biological Chemistry. 278 (13): 11676–85. PMID 12527756. doi:10.1074/jbc.M209570200. 
  14. ^ Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (Dec 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Molecular and Cellular Biology. 17 (12): 7220–9. PMC 232579Freely accessible. PMID 9372954. doi:10.1128/mcb.17.12.7220. 
  15. ^ Schneider E, Montenarh M, Wagner P (Nov 1998). "Regulation of CAK kinase activity by p53". Oncogene. 17 (21): 2733–41. PMID 9840937. doi:10.1038/sj.onc.1202504. 
  16. ^ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nature Genetics. 36 (7): 714–9. PMID 15220921. doi:10.1038/ng1387. 

Further reading[edit]


External links[edit]