Cyclin B2

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CCNB2
Identifiers
Aliases CCNB2, HsT17299, Cyclin B2
External IDs MGI: 88311 HomoloGene: 74359 GeneCards: CCNB2
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CCNB2
Genomic location for CCNB2
Band 15q22.2 Start 59,105,078 bp[1]
End 59,125,045 bp[1]
RNA expression pattern
PBB GE CCNB2 gnf1h06137 at fs.png

PBB GE CCNB2 202705 at fs.png

PBB GE CCNB2 gnf1h06136 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004701

NM_007630

RefSeq (protein)

NP_004692

NP_031656

Location (UCSC) Chr 15: 59.11 – 59.13 Mb Chr 15: 70.41 – 70.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Function[edit]

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[5]

Interactions[edit]

Cyclin B2 has been shown to interact with TGF beta receptor 2.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157456 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032218 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: CCNB2 cyclin B2". 
  6. ^ Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (Jan 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene. 18 (1): 269–75. PMID 9926943. doi:10.1038/sj.onc.1202263. 

Further reading[edit]