Cyclin K

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CCNK
Protein CCNK PDB 2i53.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CCNK, CPR4, Cyclin K
External IDs MGI: 1276106 HomoloGene: 14748 GeneCards: CCNK
RNA expression pattern
PBB GE CCNK 219273 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099402
NM_003858

NM_009832

RefSeq (protein)

NP_001092872

n/a

Location (UCSC) Chr 14: 99.48 – 99.54 Mb Chr 12: 108.18 – 108.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-K is a protein that in humans is encoded by the CCNK gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.[5]

Interactions[edit]

Cyclin K has been shown to interact with CDK9.[4] Cyclin K also interacts with HIV nef protein.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity". Molecular and Cellular Biology. 18 (7): 4291–300. PMC 109013Freely accessible. PMID 9632813. 
  4. ^ a b Fu TJ, Peng J, Lee G, Price DH, Flores O (Dec 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". The Journal of Biological Chemistry. 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912. 
  5. ^ a b "Entrez Gene: CCNK cyclin K". 
  6. ^ Khan SZ, Mitra D (Jul 2011). "Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner". The Journal of Biological Chemistry. 286 (26): 22943–22954. doi:10.1074/jbc.M110.201194. PMID 21555514. 

Further reading[edit]