|Trade names||Fertodur, Menopax, Ondonid, Ondogyne, Sexovid, others|
F-6066; H-3452; ICI-48213; bis(p-Acetoxyphenyl)-|
|AHFS/Drugs.com||International Drug Names|
|Drug class||Selective estrogen receptor modulator; Progonadotropin|
|Chemical and physical data|
|Molar mass||364.434 g/mol|
|3D model (JSmol)|
Cyclofenil (INN, USAN, BAN) (brand names Fertodur, Menopax, Ondonid, Ondogyne, Sexovid, others) is a selective estrogen receptor modulator (SERM) used as a gonadotropin stimulant which is or has been marketed in Europe, South Korea, Mexico, and Brazil, among other countries.
Cyclofenil was first introduced in 1970 under the brand name Ondogyne in France. Subsequently, it was introduced under the brand names Sexovid in Japan in 1972, Ondonvid in the United Kingdom in 1972, and Fertodur in West Germany in 1972 and Italy in 1974. It was also marketed as Sexovid in Sweden, Neoclym in Italy, and Klofenil in Turkey.
Cyclofenil was studied in the 1970s as an agent to induce ovulation in infertile women. It was then investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective. Later study of its efficacy in treating Raynaud's phenomenon in people with scleroderma also found no statistically significant benefit.
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- Ruíz-Velasco V, Rosas-Arceo J, Matute MM (1979). "Chemical inducers of ovulation: comparative results". Int J Fertil. 24: 61–4. PMID 37182.
- Torres MA, Furst DE (February 1990). "Treatment of generalized systemic sclerosis". Rheum Dis Clin North Am. 16 (1): 217–41. PMID 2406809.
- Pope J, Fenlon D, Thompson A, et al. (2000). Pope J, ed. "Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis". Cochrane Database Syst Rev (2): CD000955. doi:10.1002/14651858.CD000955. PMID 10796397.
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