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Sir Cyril Wyche PRS (c.1632 – 28 December 1707) was an English lawyer and politician.
He was born in Constantinople, Turkey, where his father, Sir Peter Wyche, was the English Ambassador. He was educated at Christ Church, Oxford with Bachelor of Arts in 1653. He received his Master of Arts (MA) in 1655 and his Doctor of Civil Law (DCL) in 1665. Between the time he received his MA and his DCL, he was knighted (1660). This is so close in time to the English Restoration that he was almost certainly a Cavalier, and may have served in the military for the Royalist cause.
He joined the bar in 1670 and became Chief Secretary for Ireland in 1692. He was a Member of Parliament for several constituences at different times, (MP for Callington (1661–1678), for East Grinstead (1681–1685), for Saltash (1685–1687), and for Preston (1702–1705)
He married three times; firstly in 1663, Elizabeth, the daughter of Sir Thomas Jermyn of Rushbrooke, Suffolk, with whom he had 2 sons (1 of whom predeceased him) and 2 daughters, secondly in 1684 Susanna, the daughter of Sir Francis Norreys of Weston on the Green, Oxfordshire and the widow of Sir Herbert Perrott of Wellington. Herefordshire and thirdly in 1692 Mary, the daughter of George Evelyn of Wotton, Surrey. Mary was the niece of John Evelyn, the diarist.
- "Fellows Details". Royal Society. Retrieved 29 April 2019.
- "WYCHE, Sir Cyril (c.1632-1707), of Gray's Inn, Westminster and Flanchford, Surr". History of Parliament Trust. Retrieved 20 April 2019.
- Sir Cyril Wyche and the Popish Plot, 1678-80, Hugh Fenning, O.P., in Seanchas Ard Macha volume 19/2, pp. 53–62, 2002
- Herbert Rix, "Wyche, Cyril", Dictionary of National Biography, 1885-1900, Volume 63